Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524
Feline Infectious Peritonitis (FIP) is caused by a systemic feline coronavirus (FCoV). Prior to June 2024, compounded FIP treatment was unavailable for prescription by veterinarians in the United States, leading to many cat owners obtaining treatment through unlicensed “black market” sources. We hyp...
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MDPI AG
2025-05-01
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| author | Kelly Larson Emma Hart Rosa Negash Wendy Novicoff Nicole Jacque Samantha Evans |
| author_facet | Kelly Larson Emma Hart Rosa Negash Wendy Novicoff Nicole Jacque Samantha Evans |
| author_sort | Kelly Larson |
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| description | Feline Infectious Peritonitis (FIP) is caused by a systemic feline coronavirus (FCoV). Prior to June 2024, compounded FIP treatment was unavailable for prescription by veterinarians in the United States, leading to many cat owners obtaining treatment through unlicensed “black market” sources. We hypothesized that clinicopathologic data could provide insight on prognostic indicators for the treatment of FIP with GS-441524. This study used data gathered via surveys from 126 cat owners who used “black market” GS-441524 for their cats. We compared bloodwork parameters over twelve weeks of treatment. None of the clinicopathologic correlates, when analyzed via two-sample <i>t</i>-tests, produced statistically significant results between cured, deceased, and relapsed groups. Within cats considered cured, it was observed that hematocrit (HCT) and white blood cell (WBC) values were within normal limits by the 2–6-week period. Cats who died during the study had lower HCT and higher WBC values within the 2–6-week period. Trends were also seen in A/G and total bilirubin (T-BIL), with deceased patients showing a higher A/G ratio and lower value than those in the cured group. Overall, these data demonstrate a lack of traditional clinicopathologic parameters which are consistently predictive of FIP therapy success. Other predictors of outcome with antiviral therapy should be pursued. |
| format | Article |
| id | doaj-art-a77f88edcd7a474ea301a4cf809f8c3a |
| institution | DOAJ |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-a77f88edcd7a474ea301a4cf809f8c3a2025-08-20T03:14:43ZengMDPI AGPathogens2076-08172025-05-0114550710.3390/pathogens14050507Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524Kelly Larson0Emma Hart1Rosa Negash2Wendy Novicoff3Nicole Jacque4Samantha Evans5Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, CO 80521, USADepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USADepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USADepartment of Orthopedic Surgery & Public Health Sciences, University of Virginia, Charlottesville, VA 22903, USAIndependent Researcher, San Jose, CA 95123, USADepartment of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, CO 80521, USAFeline Infectious Peritonitis (FIP) is caused by a systemic feline coronavirus (FCoV). Prior to June 2024, compounded FIP treatment was unavailable for prescription by veterinarians in the United States, leading to many cat owners obtaining treatment through unlicensed “black market” sources. We hypothesized that clinicopathologic data could provide insight on prognostic indicators for the treatment of FIP with GS-441524. This study used data gathered via surveys from 126 cat owners who used “black market” GS-441524 for their cats. We compared bloodwork parameters over twelve weeks of treatment. None of the clinicopathologic correlates, when analyzed via two-sample <i>t</i>-tests, produced statistically significant results between cured, deceased, and relapsed groups. Within cats considered cured, it was observed that hematocrit (HCT) and white blood cell (WBC) values were within normal limits by the 2–6-week period. Cats who died during the study had lower HCT and higher WBC values within the 2–6-week period. Trends were also seen in A/G and total bilirubin (T-BIL), with deceased patients showing a higher A/G ratio and lower value than those in the cured group. Overall, these data demonstrate a lack of traditional clinicopathologic parameters which are consistently predictive of FIP therapy success. Other predictors of outcome with antiviral therapy should be pursued.https://www.mdpi.com/2076-0817/14/5/507Feline Infectious Peritonitis (FIP)complete blood count (CBC)biochemistryprognostic indicatorsGS-441524antiviral |
| spellingShingle | Kelly Larson Emma Hart Rosa Negash Wendy Novicoff Nicole Jacque Samantha Evans Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 Pathogens Feline Infectious Peritonitis (FIP) complete blood count (CBC) biochemistry prognostic indicators GS-441524 antiviral |
| title | Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 |
| title_full | Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 |
| title_fullStr | Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 |
| title_full_unstemmed | Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 |
| title_short | Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524 |
| title_sort | prospective analysis of clinicopathologic correlates of at home feline infectious peritonitis treatment using gs 441524 |
| topic | Feline Infectious Peritonitis (FIP) complete blood count (CBC) biochemistry prognostic indicators GS-441524 antiviral |
| url | https://www.mdpi.com/2076-0817/14/5/507 |
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