Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors
Premature aging can be partially explained by inefficient autophagy (the process of cellular self-digestion that recycles intracellular components) and premature senescence (cease of cellular division without cell death activation). Autophagy and senescence are among the basic biochemical pathways i...
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| Language: | English |
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Open Exploration
2024-07-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100851/100851.pdf |
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| author | Rivka Ofir |
| author_facet | Rivka Ofir |
| author_sort | Rivka Ofir |
| collection | DOAJ |
| description | Premature aging can be partially explained by inefficient autophagy (the process of cellular self-digestion that recycles intracellular components) and premature senescence (cease of cellular division without cell death activation). Autophagy and senescence are among the basic biochemical pathways in plants and fungi suggesting that some of their metabolites have the potential to act as autophagy inducers (AI) and senescence inhibitors (SI) and to inhibit inflammation and human aging. Several compounds have already been identified: trehalose and resveratrol are natural compounds that act as AI; flavonoids found in fruit and vegetables (curcumin, quercetin, and fisetin) are among the first SI discovered so far. New AI/SI can be identified using various approaches like hypothesis-driven approach for screening receptor agonists using an in-silico library of thousands of natural compounds; cheminformatics studies of phytochemicals using docking and molecular dynamics simulation, structure similarities/mimicry in vitro, “blind” high throughput screening (HTS) of libraries of natural metabolites against relevant models, and more. This article aims to promote the use of plant and fungi novel resources to identify bioactive molecules relevant for healthy aging based on the knowledge that plants and fungi use autophagy and senescence mechanisms for their own survival and homeostasis. As autophagy and senescence are interconnected, how drugs targeting autophagy, senescence, or both could contribute to healthy aging in humans will be speculated. |
| format | Article |
| id | doaj-art-a777fdb04f624686a49137d63e159c8e |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-a777fdb04f624686a49137d63e159c8e2025-02-08T03:30:12ZengOpen ExplorationExploration of Drug Science2836-76772024-07-012436136810.37349/eds.2024.00051Plants and fungi metabolites as novel autophagy inducers and senescence inhibitorsRivka Ofir0https://orcid.org/0000-0002-7580-0163Dead Sea and Arava Science Center (DSASC), Central Arava Branch, Arava 8681500, Israel; The Regenerative Medicine & Stem Cell (RMSC) Research Center, Ben Gurion University of the Negev (BGU), Beer Sheva 84105, IsraelPremature aging can be partially explained by inefficient autophagy (the process of cellular self-digestion that recycles intracellular components) and premature senescence (cease of cellular division without cell death activation). Autophagy and senescence are among the basic biochemical pathways in plants and fungi suggesting that some of their metabolites have the potential to act as autophagy inducers (AI) and senescence inhibitors (SI) and to inhibit inflammation and human aging. Several compounds have already been identified: trehalose and resveratrol are natural compounds that act as AI; flavonoids found in fruit and vegetables (curcumin, quercetin, and fisetin) are among the first SI discovered so far. New AI/SI can be identified using various approaches like hypothesis-driven approach for screening receptor agonists using an in-silico library of thousands of natural compounds; cheminformatics studies of phytochemicals using docking and molecular dynamics simulation, structure similarities/mimicry in vitro, “blind” high throughput screening (HTS) of libraries of natural metabolites against relevant models, and more. This article aims to promote the use of plant and fungi novel resources to identify bioactive molecules relevant for healthy aging based on the knowledge that plants and fungi use autophagy and senescence mechanisms for their own survival and homeostasis. As autophagy and senescence are interconnected, how drugs targeting autophagy, senescence, or both could contribute to healthy aging in humans will be speculated.https://www.explorationpub.com/uploads/Article/A100851/100851.pdfautophagysenescenceinflammationagingfungiplantmetabolitessenescence-associated secretory phenotype (sasp) |
| spellingShingle | Rivka Ofir Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors Exploration of Drug Science autophagy senescence inflammation aging fungi plant metabolites senescence-associated secretory phenotype (sasp) |
| title | Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| title_full | Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| title_fullStr | Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| title_full_unstemmed | Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| title_short | Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| title_sort | plants and fungi metabolites as novel autophagy inducers and senescence inhibitors |
| topic | autophagy senescence inflammation aging fungi plant metabolites senescence-associated secretory phenotype (sasp) |
| url | https://www.explorationpub.com/uploads/Article/A100851/100851.pdf |
| work_keys_str_mv | AT rivkaofir plantsandfungimetabolitesasnovelautophagyinducersandsenescenceinhibitors |