Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience
<b>Background:</b> Kawasaki disease (KD) is an acute inflammatory vasculitis with a particularly high incidence of coronary artery complications and constitutes a significant cause of acquired heart disease in children and young adults. <b>Methods:</b> We conducted a retrospe...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/6/656 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204392069791744 |
|---|---|
| author | Cristina Ramona Rădulescu Anca Cristina Drăgănescu Diana Maria Băncilă Anuţa Bilaşco Mihai-Rareş Bădescu Doina Anca Pleşca |
| author_facet | Cristina Ramona Rădulescu Anca Cristina Drăgănescu Diana Maria Băncilă Anuţa Bilaşco Mihai-Rareş Bădescu Doina Anca Pleşca |
| author_sort | Cristina Ramona Rădulescu |
| collection | DOAJ |
| description | <b>Background:</b> Kawasaki disease (KD) is an acute inflammatory vasculitis with a particularly high incidence of coronary artery complications and constitutes a significant cause of acquired heart disease in children and young adults. <b>Methods:</b> We conducted a retrospective analysis of consecutive patients aged 0–18 years hospitalized at the “Prof. Dr. Matei Balş” National Institute of Infectious Diseases in Bucharest with Kawasaki disease over a period of 6 years (2018–2023). <b>Results:</b> A total of 25 children were discharged from hospital with this diagnosis during the analyzed period. The mean age was 2.9 years, and 56% were boys. Fever ≥5 days was present in all cases, and the most frequent additional sign was the presence of oral changes. Patients were treated according to in-effect guidelines with intravenous immunoglobulin (IVIG) (100%) and acetylsalicylic acid (68%). Only two cases were considered IVIG resistant and received a second IVIG infusion. Only mild cardiovascular changes were noted in echocardiography: mild coronary artery dilatation (21.7% of cases), mild valvular regurgitation, and small pericardial effusion. Infants displayed less inflammation and higher percentages of leukocytosis, developed an increase in platelet count sooner, received IVIG faster, and had longer hospital stays. Outcomes were generally favorable, and 92% of children were discharged, while the two remaining patients were transferred to other centers. No deaths were recorded. <b>Conclusions:</b> To our knowledge, this is the largest contemporary Romanian cohort of Kawasaki disease published to date, outlining the local diagnostic process, therapeutic strategies, and early outcomes of Kawasaki disease. |
| format | Article |
| id | doaj-art-a777bd221f184c088fe17bd400cff89e |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-a777bd221f184c088fe17bd400cff89e2025-08-20T02:11:18ZengMDPI AGDiagnostics2075-44182025-03-0115665610.3390/diagnostics15060656Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center ExperienceCristina Ramona Rădulescu0Anca Cristina Drăgănescu1Diana Maria Băncilă2Anuţa Bilaşco3Mihai-Rareş Bădescu4Doina Anca Pleşca5Department of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania“Prof. Dr. Matei Balş” National Institute of Infectious Diseases, 021105 Bucharest, RomaniaDepartment of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania<b>Background:</b> Kawasaki disease (KD) is an acute inflammatory vasculitis with a particularly high incidence of coronary artery complications and constitutes a significant cause of acquired heart disease in children and young adults. <b>Methods:</b> We conducted a retrospective analysis of consecutive patients aged 0–18 years hospitalized at the “Prof. Dr. Matei Balş” National Institute of Infectious Diseases in Bucharest with Kawasaki disease over a period of 6 years (2018–2023). <b>Results:</b> A total of 25 children were discharged from hospital with this diagnosis during the analyzed period. The mean age was 2.9 years, and 56% were boys. Fever ≥5 days was present in all cases, and the most frequent additional sign was the presence of oral changes. Patients were treated according to in-effect guidelines with intravenous immunoglobulin (IVIG) (100%) and acetylsalicylic acid (68%). Only two cases were considered IVIG resistant and received a second IVIG infusion. Only mild cardiovascular changes were noted in echocardiography: mild coronary artery dilatation (21.7% of cases), mild valvular regurgitation, and small pericardial effusion. Infants displayed less inflammation and higher percentages of leukocytosis, developed an increase in platelet count sooner, received IVIG faster, and had longer hospital stays. Outcomes were generally favorable, and 92% of children were discharged, while the two remaining patients were transferred to other centers. No deaths were recorded. <b>Conclusions:</b> To our knowledge, this is the largest contemporary Romanian cohort of Kawasaki disease published to date, outlining the local diagnostic process, therapeutic strategies, and early outcomes of Kawasaki disease.https://www.mdpi.com/2075-4418/15/6/656Kawasakiprolonged feverIVIGaspirinechocardiographycoronary artery lesions |
| spellingShingle | Cristina Ramona Rădulescu Anca Cristina Drăgănescu Diana Maria Băncilă Anuţa Bilaşco Mihai-Rareş Bădescu Doina Anca Pleşca Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience Diagnostics Kawasaki prolonged fever IVIG aspirin echocardiography coronary artery lesions |
| title | Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience |
| title_full | Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience |
| title_fullStr | Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience |
| title_full_unstemmed | Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience |
| title_short | Contemporary Diagnosis, Management, and Early Outcomes in Children with Kawasaki Disease in Romania: A Single-Center Experience |
| title_sort | contemporary diagnosis management and early outcomes in children with kawasaki disease in romania a single center experience |
| topic | Kawasaki prolonged fever IVIG aspirin echocardiography coronary artery lesions |
| url | https://www.mdpi.com/2075-4418/15/6/656 |
| work_keys_str_mv | AT cristinaramonaradulescu contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience AT ancacristinadraganescu contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience AT dianamariabancila contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience AT anutabilasco contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience AT mihairaresbadescu contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience AT doinaancaplesca contemporarydiagnosismanagementandearlyoutcomesinchildrenwithkawasakidiseaseinromaniaasinglecenterexperience |