Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis
Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/574817 |
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| author | Luis Rodríguez-Rodríguez Raquel López-Mejías Mercedes García-Bermúdez Carlos González-Juanatey Miguel A. González-Gay Javier Martín |
| author_facet | Luis Rodríguez-Rodríguez Raquel López-Mejías Mercedes García-Bermúdez Carlos González-Juanatey Miguel A. González-Gay Javier Martín |
| author_sort | Luis Rodríguez-Rodríguez |
| collection | DOAJ |
| description | Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studies have confirmed the role of genetic factors in the development of the atherogenesis observed in RA. In this regard, besides a strong association between the HLA-DRB1*04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G>A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A>C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. Despite considerable effort to decipher the genetic basis of CV disease in RA, further studies are required to better establish the genetic influence in the increased risk of CV events observed in patients with RA. |
| format | Article |
| id | doaj-art-a77408d1b72d4f74a893b4a212f933b3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a77408d1b72d4f74a893b4a212f933b32025-02-03T05:46:08ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/574817574817Genetic Markers of Cardiovascular Disease in Rheumatoid ArthritisLuis Rodríguez-Rodríguez0Raquel López-Mejías1Mercedes García-Bermúdez2Carlos González-Juanatey3Miguel A. González-Gay4Javier Martín5Department of Rheumatology, Hospital Clínico San Carlos, c/Profesor Martín Lagos s/n, 28040 Madrid, SpainDepartment of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avenida Herrera Oria s/n, 39011 Santander, SpainInstituto de Parasitología y Biomedicina López-Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, Armilla, 18100 Granada, SpainCardiology Division, Hospital Xeral-Calde, c/Dr. Ochoa s/n, 27004 Lugo, SpainDepartment of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avenida Herrera Oria s/n, 39011 Santander, SpainInstituto de Parasitología y Biomedicina López-Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, Armilla, 18100 Granada, SpainCardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studies have confirmed the role of genetic factors in the development of the atherogenesis observed in RA. In this regard, besides a strong association between the HLA-DRB1*04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G>A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A>C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA. Despite considerable effort to decipher the genetic basis of CV disease in RA, further studies are required to better establish the genetic influence in the increased risk of CV events observed in patients with RA.http://dx.doi.org/10.1155/2012/574817 |
| spellingShingle | Luis Rodríguez-Rodríguez Raquel López-Mejías Mercedes García-Bermúdez Carlos González-Juanatey Miguel A. González-Gay Javier Martín Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis Mediators of Inflammation |
| title | Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis |
| title_full | Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis |
| title_fullStr | Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis |
| title_full_unstemmed | Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis |
| title_short | Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis |
| title_sort | genetic markers of cardiovascular disease in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2012/574817 |
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