High-fat diet and chronic restraint stress exacerbate anxiety-depressive behaviors via astrocytic A1 phenotype transformation

High-fat diet and chronic restraint stress exacerbate anxiety-depressive behaviors via astrocytic A1 phenotype transformation

Abstract Obesity and depression are likely to co-occur. However, there are few reports on the relationship between obesity and depression. We aimed to investigate the effect of high-fat diet combined with chronic restraint stress on depressive-like behaviors, focusing on the phenotypic transformatio...

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Bibliographic Details
Main Authors: Ran Ding, Linyin Gao, Xindi Wang, Jinxia Yang, Xuemei Han, Shuailong Fei, Jian Wang, Xiujun Zhang, Haitao Wang, Xueliang Shang, Lei Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Depression
High fat diet
Astrocyte
Wnt/β-catenin signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-99355-4
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