Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study
Objective To compare the efficacy of 2 L and 3 L polyethylene glycol (PEG) electrolyte solution for bowel preparation in a real-world setting. Methods A real-world, single-center cohort study was conducted on the individuals undergoing colonoscopy in Department of Gastroenterology of Chengdu Thi...
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Editorial Office of Journal of Army Medical University
2025-02-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | https://aammt.tmmu.edu.cn/html/202407055.html |
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| author | LI Jiaojun LI Jiaojun TAN Xianhao TAN Xianhao ZHANG Chen |
| author_facet | LI Jiaojun LI Jiaojun TAN Xianhao TAN Xianhao ZHANG Chen |
| author_sort | LI Jiaojun |
| collection | DOAJ |
| description | Objective To compare the efficacy of 2 L and 3 L polyethylene glycol (PEG) electrolyte solution for bowel preparation in a real-world setting. Methods A real-world, single-center cohort study was conducted on the individuals undergoing colonoscopy in Department of Gastroenterology of Chengdu Third People’s Hospital between May and October 2023. Based on our inclusion and exclusion criteria, they were given 2 L (n=4 684) and 3 L (n=3 700) PEG electrolyte solution for bowel preparation. The primary outcome indicator was the adequacy of bowel preparation by Boston bowel preparation score (BBPS). Secondary outcome indicators included the BBPS score, polyp detection rate (PDR), tolerability, compliance, and incidence of adverse events. Results The adequacy rate of bowel preparation was 94.35% in the 3 L group, significantly higher than that of the 2 L group (91.29%, P<0.001). The 3 L group obtained a higher BBPS score then the 2 L group (6.92±1.06 vs 6.81±1.14, P<0.001). But there was no statistical difference in the PDR between the 2 groups (P=0.073). And the rate of PEG completion (P=0.810), administration of low residue diet as required (P=0.094) or use of dimethicone (P=0.072) were comparable between the 2 groups. However, the incidences of vomiting (4.5% vs 3.2%, P=0.002), abdominal discomfort (5.0% vs 3.9%, P=0.011) and sleep disturbance (18.0% vs 14.6%, P<0.001) were obviously higher in the 3 L group than the 2 L group. Conclusion In a real-world setting, 2 L PEG is a considerably safe and effective regimen for bowel preparation.
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| format | Article |
| id | doaj-art-a76da9d4051b441eb8e834cb7885cea2 |
| institution | Kabale University |
| issn | 2097-0927 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj-art-a76da9d4051b441eb8e834cb7885cea22025-02-10T01:14:57ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272025-02-0147325526110.16016/j.2097-0927.202407055Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world studyLI Jiaojun0LI Jiaojun1TAN Xianhao2TAN Xianhao3ZHANG Chen4School of Clinical Medicine， North Sichuan Medical College， Nanchong， SichuanDepartment of Gastroenterology， Chengdu Third People’s Hospital， Chengdu， SichuanDepartment of Gastroenterology， Chengdu Third People’s Hospital， Chengdu， SichuanCollege of Clinical Medicine， Southwest Medical University， Luzhou， Sichuan， ChinaDepartment of Gastroenterology， Chengdu Third People’s Hospital， Chengdu， Sichuan Objective To compare the efficacy of 2 L and 3 L polyethylene glycol (PEG) electrolyte solution for bowel preparation in a real-world setting. Methods A real-world, single-center cohort study was conducted on the individuals undergoing colonoscopy in Department of Gastroenterology of Chengdu Third People’s Hospital between May and October 2023. Based on our inclusion and exclusion criteria, they were given 2 L (n=4 684) and 3 L (n=3 700) PEG electrolyte solution for bowel preparation. The primary outcome indicator was the adequacy of bowel preparation by Boston bowel preparation score (BBPS). Secondary outcome indicators included the BBPS score, polyp detection rate (PDR), tolerability, compliance, and incidence of adverse events. Results The adequacy rate of bowel preparation was 94.35% in the 3 L group, significantly higher than that of the 2 L group (91.29%, P<0.001). The 3 L group obtained a higher BBPS score then the 2 L group (6.92±1.06 vs 6.81±1.14, P<0.001). But there was no statistical difference in the PDR between the 2 groups (P=0.073). And the rate of PEG completion (P=0.810), administration of low residue diet as required (P=0.094) or use of dimethicone (P=0.072) were comparable between the 2 groups. However, the incidences of vomiting (4.5% vs 3.2%, P=0.002), abdominal discomfort (5.0% vs 3.9%, P=0.011) and sleep disturbance (18.0% vs 14.6%, P<0.001) were obviously higher in the 3 L group than the 2 L group. Conclusion In a real-world setting, 2 L PEG is a considerably safe and effective regimen for bowel preparation. https://aammt.tmmu.edu.cn/html/202407055.htmlpolyethylene glycolbowel preparationcomparative effectiveness researchreal world |
| spellingShingle | LI Jiaojun LI Jiaojun TAN Xianhao TAN Xianhao ZHANG Chen Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study 陆军军医大学学报 polyethylene glycol bowel preparation comparative effectiveness research real world |
| title | Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study |
| title_full | Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study |
| title_fullStr | Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study |
| title_full_unstemmed | Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study |
| title_short | Efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation: a real-world study |
| title_sort | efficacy of 2 l versus 3 l polyethylene glycol in bowel preparation a real world study |
| topic | polyethylene glycol bowel preparation comparative effectiveness research real world |
| url | https://aammt.tmmu.edu.cn/html/202407055.html |
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