The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis
The relationship between the classical cardiac biomarker and acute myocardial infarction (STEMI) in patients with COVID-19 is far from being elucidated. Furthermore, superoxide dismutase (SOD), a marker for oxidative stress, was associated with cardiac ischemia. Also, Galectin-3 is significant for d...
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2024-10-01
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| author | Razan Al Namat Letiția Doina Duceac Liliana Chelaru Cristina Dimitriu Amin Bazyani Andrei Tarus Alberto Bacusca Adrian Roșca Dina Al Namat Lucian Ionuț Livanu Elena Țarcă Grigore Tinică |
| author_facet | Razan Al Namat Letiția Doina Duceac Liliana Chelaru Cristina Dimitriu Amin Bazyani Andrei Tarus Alberto Bacusca Adrian Roșca Dina Al Namat Lucian Ionuț Livanu Elena Țarcă Grigore Tinică |
| author_sort | Razan Al Namat |
| collection | DOAJ |
| description | The relationship between the classical cardiac biomarker and acute myocardial infarction (STEMI) in patients with COVID-19 is far from being elucidated. Furthermore, superoxide dismutase (SOD), a marker for oxidative stress, was associated with cardiac ischemia. Also, Galectin-3 is significant for defining the relationship between cardiac fibrosis and COVID-19. There are no studies on the effect of SARS-CoV-2 virus infection and vaccination on patients with STEMI and biomarkers above-mentioned. Aim: our single-center prospective study assesses the relationship between COVID-19 infection with/without vaccination and the value of SOD and Galectin-3 in STEMI patients. Material and methods: In total, 93 patients with STEMI and SARS-CoV-2 virus infection were included in the analysis, patients were divided in two groups based on COVID-19 vaccination status. Echocardiographic and laboratory investigations for cardiac ischemia, oxidative stress, and cardiac fibrosis biomarkers were investigated. Results: In total, 93 patients were included, the majority of which were male (72.0%), 45.2% (<i>n</i> = 42) were vaccinated against SARS-CoV-2; the mean age of vaccinated patients is 62 years, and 57% (<i>n</i> = 53) are smokers; blood pressure is found with a higher frequency in unvaccinated people (62.7%) compared to 28.6% in vaccinated people (<i>p</i> = 0.015), and 90.5% of the vaccinated people presented STEMI, compared with 96.1% of the unvaccinated ones. Revascularization with one stent was achieved in 47.6% of the vaccinated people and 72.5% for the unvaccinated people (<i>p</i> = 0.015). Galectin-3 was slightly more reduced in the vaccinated patients compared to the unvaccinated patients (0.73 vs. 0.99; <i>p</i> = 0.202), and the average level of Cu/ZnSOD was slightly more reduced in vaccinated patients compared to the unvaccinated patients (0.84 vs. 0.91; <i>p</i> = 0.740). Conclusions: Regarding patient’s SARS-CoV-2 infection functional status, the results from our single-center analysis did not find a statistically significant decrease in oxidative stress and cardiac fibrosis biomarkers along with cardiovascular complication following STEMI treated with percutaneous coronary angioplasty (PCI) in the case of patients with COVID-19 vaccination compared with patients who did not receive COVID-19 vaccine. Anyway, our data suggest that contemporary PCI techniques may offer an alternative revascularization strategy that enables complex CAD COVID-19 patients to be safely discharged from hospital. |
| format | Article |
| id | doaj-art-a76c5f6efe704f41bd1c94d0f31779fc |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-10-01 |
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| spelling | doaj-art-a76c5f6efe704f41bd1c94d0f31779fc2024-11-26T18:10:00ZengMDPI AGLife2075-17292024-10-011411135010.3390/life14111350The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience AnalysisRazan Al Namat0Letiția Doina Duceac1Liliana Chelaru2Cristina Dimitriu3Amin Bazyani4Andrei Tarus5Alberto Bacusca6Adrian Roșca7Dina Al Namat8Lucian Ionuț Livanu9Elena Țarcă10Grigore Tinică11Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800008 Galati, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, Romania“Saint Mary” Emergency Children Hospital, 700309 Iassy, RomaniaDepartment of Surgery II—Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine and Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Surgery II—Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iassy, RomaniaThe relationship between the classical cardiac biomarker and acute myocardial infarction (STEMI) in patients with COVID-19 is far from being elucidated. Furthermore, superoxide dismutase (SOD), a marker for oxidative stress, was associated with cardiac ischemia. Also, Galectin-3 is significant for defining the relationship between cardiac fibrosis and COVID-19. There are no studies on the effect of SARS-CoV-2 virus infection and vaccination on patients with STEMI and biomarkers above-mentioned. Aim: our single-center prospective study assesses the relationship between COVID-19 infection with/without vaccination and the value of SOD and Galectin-3 in STEMI patients. Material and methods: In total, 93 patients with STEMI and SARS-CoV-2 virus infection were included in the analysis, patients were divided in two groups based on COVID-19 vaccination status. Echocardiographic and laboratory investigations for cardiac ischemia, oxidative stress, and cardiac fibrosis biomarkers were investigated. Results: In total, 93 patients were included, the majority of which were male (72.0%), 45.2% (<i>n</i> = 42) were vaccinated against SARS-CoV-2; the mean age of vaccinated patients is 62 years, and 57% (<i>n</i> = 53) are smokers; blood pressure is found with a higher frequency in unvaccinated people (62.7%) compared to 28.6% in vaccinated people (<i>p</i> = 0.015), and 90.5% of the vaccinated people presented STEMI, compared with 96.1% of the unvaccinated ones. Revascularization with one stent was achieved in 47.6% of the vaccinated people and 72.5% for the unvaccinated people (<i>p</i> = 0.015). Galectin-3 was slightly more reduced in the vaccinated patients compared to the unvaccinated patients (0.73 vs. 0.99; <i>p</i> = 0.202), and the average level of Cu/ZnSOD was slightly more reduced in vaccinated patients compared to the unvaccinated patients (0.84 vs. 0.91; <i>p</i> = 0.740). Conclusions: Regarding patient’s SARS-CoV-2 infection functional status, the results from our single-center analysis did not find a statistically significant decrease in oxidative stress and cardiac fibrosis biomarkers along with cardiovascular complication following STEMI treated with percutaneous coronary angioplasty (PCI) in the case of patients with COVID-19 vaccination compared with patients who did not receive COVID-19 vaccine. Anyway, our data suggest that contemporary PCI techniques may offer an alternative revascularization strategy that enables complex CAD COVID-19 patients to be safely discharged from hospital.https://www.mdpi.com/2075-1729/14/11/1350acute myocardial infarction (STEMI)oxidative stresscardiac fibrosisCOVID-19 vaccinationSARS-CoV-2 infection |
| spellingShingle | Razan Al Namat Letiția Doina Duceac Liliana Chelaru Cristina Dimitriu Amin Bazyani Andrei Tarus Alberto Bacusca Adrian Roșca Dina Al Namat Lucian Ionuț Livanu Elena Țarcă Grigore Tinică The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis Life acute myocardial infarction (STEMI) oxidative stress cardiac fibrosis COVID-19 vaccination SARS-CoV-2 infection |
| title | The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis |
| title_full | The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis |
| title_fullStr | The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis |
| title_full_unstemmed | The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis |
| title_short | The Impact of COVID-19 Vaccination on Oxidative Stress and Cardiac Fibrosis Biomarkers in Patients with Acute Myocardial Infarction (STEMI), a Single-Center Experience Analysis |
| title_sort | impact of covid 19 vaccination on oxidative stress and cardiac fibrosis biomarkers in patients with acute myocardial infarction stemi a single center experience analysis |
| topic | acute myocardial infarction (STEMI) oxidative stress cardiac fibrosis COVID-19 vaccination SARS-CoV-2 infection |
| url | https://www.mdpi.com/2075-1729/14/11/1350 |
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