Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer

Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer

CKLF (chemokine-like factor)-like MARVEL transmembrane domain-containing family member 4 (CMTM4), belonging to the CMTM family of transmembrane domain proteins, plays a significant role in the initiation, progression, and metastasis of cancer. Nevertheless, its involvement in tumor immunity remains...

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Main Authors: Bo Yin, Wei Wang, Ang Li, Mengjie Li, Huijuan Zhou, Haoran Hu, Jianyi Ding, Yashi Zhu, Xinxin Xu, Meiqin Yang, Tiefeng Huang, Yifan Kou, Zilale Rahim, Baoyou Huang, Lingfei Han
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011776.full
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