Modulation of ERK and AKT pathways as the potential therapeutic targets for Toxoplasma gondii infection
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, which can infect humans through oocysts or undercooked meat. It can cause varying symptoms, including congenital toxoplasmosis. Early detection and treatment are beneficial, and antimicrobial treatment can prevent or resolve symptom...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Tabriz
2024-03-01
|
| Series: | Journal of Zoonotic Diseases |
| Subjects: | |
| Online Access: | https://jzd.tabrizu.ac.ir/article_17741.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, which can infect
humans through oocysts or undercooked meat. It can cause varying symptoms, including
congenital toxoplasmosis. Early detection and treatment are beneficial, and antimicrobial
treatment can prevent or resolve symptoms. The disease has a complex life cycle, with
felids being the definitive host. Understanding the signaling pathways is crucial for
effective therapeutic strategies. Toxoplasma invasion is regulated by the microtubule
cytoskeleton, affecting macrophages and innate immunity cells. Calcium binding
proteins and focal adhesion kinase-2 have been identified as key regulators of calcium
signaling in Toxoplasma. Calcium signaling is crucial for parasite biology and drug
development. The ERK pathway plays a significant role in host-parasite interactions and
immune responses. This pathway plays a critical role in the spread of Toxoplasma by
manipulating host cell migration. Toxoplasma infection can activate the ERK signaling
pathway, leading to the inhibition of apoptosis in host cells. This inhibition of apoptosis
is believed to have a positive effect on the survival and replication of the parasite in the
host. The Akt signaling pathway, also known as the PI3K/Akt pathway, is crucial in
parasitic diseases, modulating host immune responses and parasite survival. Host AKT
activation is important for T. gondii proliferation which is related to reduction of ROS in
host cells. More investigation is required to fully understand how these signals contribute
to the pathophysiology of Toxoplasma infection and to identify possible therapeutic
targets for the management of parasitic illnesses.
|
|---|---|
| ISSN: | 2717-2910 |