Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II)
Background: Heart failure (HF) affects approximately 64.3 million people worldwide. Despite notable progress over the past two decades in advancing the understanding of heart failure in Africa–a condition often more lethal than many cancers–important knowledge gaps persist. These include outdated da...
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| Language: | English |
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Ubiquity Press
2025-07-01
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| Series: | Global Heart |
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| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1449 |
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| author | Karen Sliwa Simon Stewart Charle Viljoen Shaazia Allie Julia Hahnle Albertino Damasceno Neusa Jessen Mahmoud Sani George Nel Duard Smith Beth Davison Gad Cotter |
| author_facet | Karen Sliwa Simon Stewart Charle Viljoen Shaazia Allie Julia Hahnle Albertino Damasceno Neusa Jessen Mahmoud Sani George Nel Duard Smith Beth Davison Gad Cotter |
| author_sort | Karen Sliwa |
| collection | DOAJ |
| description | Background: Heart failure (HF) affects approximately 64.3 million people worldwide. Despite notable progress over the past two decades in advancing the understanding of heart failure in Africa–a condition often more lethal than many cancers–important knowledge gaps persist. These include outdated data on access to care and a lack of information regarding the incidence, aetiology, availability, and affordability of HF medications. Objectives: To prospectively characterise the contemporary incidence, epidemiology, clinical presentation, and health outcomes of acute HF among a large, representative cohort of patients presenting to hospitals across diverse communities in Africa. Methods: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) is a pragmatic, multicentre, observational cohort study coordinated by the Pan-African Society of Cardiology (PASCAR). All 27 PASCAR member countries were invited to participate, along with over 5,000 clinicians from the PASCAR database. The survey comprises two components. First, a platform collecting data on each hospital’s catchment population, human resources, presence of specialised cardiology services, availability of diagnostic tools, and access to essential heart failure treatments. Second, a prospective observational study capturing all acute heart failure presentations to participating hospitals over seven weekdays within an 8-week period (from the start of surveillance). Data were collected on clinical characteristics and outcomes to discharge, 30 days, and six months. The study commenced in mid-2024 and includes approximately 50 hospitals across 16 countries spanning all major regions of the African continent. Conclusions: When completed, THESUS-HF II will be the largest and most comprehensive study of acute HF to date in Africa. It will provide invaluable insights into the contemporary characteristics and burden of acute HF in Africa, whilst indicating what is needed to improve health care planning and, ultimately, patient outcomes. |
| format | Article |
| id | doaj-art-a7633dcb5f234cd1bc75dceaef332625 |
| institution | Kabale University |
| issn | 2211-8179 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj-art-a7633dcb5f234cd1bc75dceaef3326252025-08-21T12:35:35ZengUbiquity PressGlobal Heart2211-81792025-07-01201646410.5334/gh.14491430Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II)Karen Sliwa0https://orcid.org/0000-0002-8272-0911Simon Stewart1https://orcid.org/0000-0001-9032-8998Charle Viljoen2https://orcid.org/0000-0001-7246-4136Shaazia Allie3https://orcid.org/0000-0002-3342-2790Julia Hahnle4https://orcid.org/0009-0009-6178-4893Albertino Damasceno5https://orcid.org/0000-0003-0925-494XNeusa Jessen6https://orcid.org/0000-0002-6304-7557Mahmoud Sani7https://orcid.org/0000-0001-8946-129XGeorge Nel8Duard Smith9Beth Davison10https://orcid.org/0000-0003-2374-6449Gad Cotter11https://orcid.org/0000-0002-9613-3339Cape Heart Institute, Department of Medicine & Cardiology, University of Cape TownCape Heart Institute, Department of Medicine & Cardiology, University of Cape Town, ZA; Institute of Health Research, University of Notre Dame Australia, Fremantle, WACape Heart Institute, Department of Medicine & Cardiology, University of Cape TownCape Heart Institute, Department of Medicine & Cardiology, University of Cape TownCape Heart Institute, Department of Medicine & Cardiology, University of Cape TownDepartment of Medicine, Maputo Central Hospital, Eduardo Mondlane UniversityDepartment of Medicine, Maputo Central Hospital, Eduardo Mondlane UniversityDepart of Medicine, Division of Cardiology, Aminu Kano Teaching Hospital, Bayero UniversityPan-African Society of Cardiology, Cape TownPan-African Society of Cardiology, Cape TownMomentum Research Inc. Durham, NCMomentum Research Inc. Durham, NCBackground: Heart failure (HF) affects approximately 64.3 million people worldwide. Despite notable progress over the past two decades in advancing the understanding of heart failure in Africa–a condition often more lethal than many cancers–important knowledge gaps persist. These include outdated data on access to care and a lack of information regarding the incidence, aetiology, availability, and affordability of HF medications. Objectives: To prospectively characterise the contemporary incidence, epidemiology, clinical presentation, and health outcomes of acute HF among a large, representative cohort of patients presenting to hospitals across diverse communities in Africa. Methods: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) is a pragmatic, multicentre, observational cohort study coordinated by the Pan-African Society of Cardiology (PASCAR). All 27 PASCAR member countries were invited to participate, along with over 5,000 clinicians from the PASCAR database. The survey comprises two components. First, a platform collecting data on each hospital’s catchment population, human resources, presence of specialised cardiology services, availability of diagnostic tools, and access to essential heart failure treatments. Second, a prospective observational study capturing all acute heart failure presentations to participating hospitals over seven weekdays within an 8-week period (from the start of surveillance). Data were collected on clinical characteristics and outcomes to discharge, 30 days, and six months. The study commenced in mid-2024 and includes approximately 50 hospitals across 16 countries spanning all major regions of the African continent. Conclusions: When completed, THESUS-HF II will be the largest and most comprehensive study of acute HF to date in Africa. It will provide invaluable insights into the contemporary characteristics and burden of acute HF in Africa, whilst indicating what is needed to improve health care planning and, ultimately, patient outcomes.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1449acute heart failureepidemiologyprognosisclinical profilehealth economicscardiomyopathyafrica |
| spellingShingle | Karen Sliwa Simon Stewart Charle Viljoen Shaazia Allie Julia Hahnle Albertino Damasceno Neusa Jessen Mahmoud Sani George Nel Duard Smith Beth Davison Gad Cotter Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) Global Heart acute heart failure epidemiology prognosis clinical profile health economics cardiomyopathy africa |
| title | Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) |
| title_full | Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) |
| title_fullStr | Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) |
| title_full_unstemmed | Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) |
| title_short | Generating Important Insights into the Spectrum and Outcomes of Acute Heart Failure Across the African Continent: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) |
| title_sort | generating important insights into the spectrum and outcomes of acute heart failure across the african continent the sub saharan africa survey of heart failure thesus hf ii |
| topic | acute heart failure epidemiology prognosis clinical profile health economics cardiomyopathy africa |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1449 |
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