Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma
Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs are mostly benign, arise from the adrenal medulla a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-07-01
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| Series: | Endocrines |
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| Online Access: | https://www.mdpi.com/2673-396X/5/3/19 |
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| author | Edlira Luca Andrea Abate Katharina Wang Stefan Bornstein Sandra Sigala Felix Beuschlein Svenja Nölting Constanze Hantel |
| author_facet | Edlira Luca Andrea Abate Katharina Wang Stefan Bornstein Sandra Sigala Felix Beuschlein Svenja Nölting Constanze Hantel |
| author_sort | Edlira Luca |
| collection | DOAJ |
| description | Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs are mostly benign, arise from the adrenal medulla and have a variable prognosis, with 10% of PCCs resulting in metastasis. Genetic background strongly influences metastasis of PCCs, and no reliable biomarkers that predict metastatic behavior exist to date. Current therapeutic strategies for both ACCs and PCCs are overall limited. Thus, novel preclinical models and drug screening approaches need to be established to aid in the identification of more promising drugs and treatment schemes. In this review, we summarize the currently available human and murine cell lines for both tumor entities. |
| format | Article |
| id | doaj-art-a75ff68657c54953a66152da4a7cf44d |
| institution | OA Journals |
| issn | 2673-396X |
| language | English |
| publishDate | 2024-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj-art-a75ff68657c54953a66152da4a7cf44d2025-08-20T01:55:26ZengMDPI AGEndocrines2673-396X2024-07-015326127610.3390/endocrines5030019Human and Murine Cell Lines for Adrenocortical Carcinoma and PheochromocytomaEdlira Luca0Andrea Abate1Katharina Wang2Stefan Bornstein3Sandra Sigala4Felix Beuschlein5Svenja Nölting6Constanze Hantel7Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandDepartment of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1/5, 80336 München, GermanyDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandSection of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124 Brescia, ItalyDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), 8091 Zurich, SwitzerlandAdrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs are mostly benign, arise from the adrenal medulla and have a variable prognosis, with 10% of PCCs resulting in metastasis. Genetic background strongly influences metastasis of PCCs, and no reliable biomarkers that predict metastatic behavior exist to date. Current therapeutic strategies for both ACCs and PCCs are overall limited. Thus, novel preclinical models and drug screening approaches need to be established to aid in the identification of more promising drugs and treatment schemes. In this review, we summarize the currently available human and murine cell lines for both tumor entities.https://www.mdpi.com/2673-396X/5/3/19adrenocortical carcinomapheochromocytomacell lineshumanmurineNCI-H295 |
| spellingShingle | Edlira Luca Andrea Abate Katharina Wang Stefan Bornstein Sandra Sigala Felix Beuschlein Svenja Nölting Constanze Hantel Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma Endocrines adrenocortical carcinoma pheochromocytoma cell lines human murine NCI-H295 |
| title | Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma |
| title_full | Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma |
| title_fullStr | Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma |
| title_full_unstemmed | Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma |
| title_short | Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma |
| title_sort | human and murine cell lines for adrenocortical carcinoma and pheochromocytoma |
| topic | adrenocortical carcinoma pheochromocytoma cell lines human murine NCI-H295 |
| url | https://www.mdpi.com/2673-396X/5/3/19 |
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