Distraction Osteogenesis: A Comprehensive Review
Distraction osteogenesis (DO) is a process which uses the bone’s natural healing tendencies to repair and lengthen pathologic, missing, or malformed bone. The mechanism of DO mimics the pathway that the body uses in any other fracture repair however the location of the fracture is carefully controll...
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| Format: | Article |
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MDPI AG
2024-11-01
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| Series: | Applied Biosciences |
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| Online Access: | https://www.mdpi.com/2813-0464/3/4/32 |
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| author | Babapelumi Adejuyigbe Mohini Gharpure Charlotte F. Wahle Jennifer R. Kallini |
| author_facet | Babapelumi Adejuyigbe Mohini Gharpure Charlotte F. Wahle Jennifer R. Kallini |
| author_sort | Babapelumi Adejuyigbe |
| collection | DOAJ |
| description | Distraction osteogenesis (DO) is a process which uses the bone’s natural healing tendencies to repair and lengthen pathologic, missing, or malformed bone. The mechanism of DO mimics the pathway that the body uses in any other fracture repair however the location of the fracture is carefully controlled by a surgical osteotomy. Postoperatively, the bone is allowed to begin its natural healing process, with the lengthener applying constant tension and thus re-initiating the process of healing along the length of the distraction gap. Current clinical indications for DO include limb length discrepancy, congenital bone length deformity, large bone defects, and extremity reconstruction due to hypoplasia or limb salvage procedures. The risks of DO include soft tissue complications, relapse or improper correction, cost or resource-related challenges, and psychosocial stigmas surrounding long treatment durations and the necessity of wearing the distraction lengthening hardware. Future directions for DO include supplements to the bone regeneration process (such as growth factors and/or mechanical stimulation) or improvements to the distractor device itself (changes in material and/or the structure of the device itself). This review aims to offer a comprehensive summary of the indications, underlying biological mechanisms, and practical considerations when implementing the use of distraction osteogenesis in clinical practice. |
| format | Article |
| id | doaj-art-a753ff3dd9a24acd8439dd7a806edd99 |
| institution | OA Journals |
| issn | 2813-0464 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Biosciences |
| spelling | doaj-art-a753ff3dd9a24acd8439dd7a806edd992025-08-20T02:00:50ZengMDPI AGApplied Biosciences2813-04642024-11-013450351610.3390/applbiosci3040032Distraction Osteogenesis: A Comprehensive ReviewBabapelumi Adejuyigbe0Mohini Gharpure1Charlotte F. Wahle2Jennifer R. Kallini3David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USAMedical College of Georgia, Augusta University, Augusta, GA 30912, USADavid Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USADepartment of Orthopedic Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA 90404, USADistraction osteogenesis (DO) is a process which uses the bone’s natural healing tendencies to repair and lengthen pathologic, missing, or malformed bone. The mechanism of DO mimics the pathway that the body uses in any other fracture repair however the location of the fracture is carefully controlled by a surgical osteotomy. Postoperatively, the bone is allowed to begin its natural healing process, with the lengthener applying constant tension and thus re-initiating the process of healing along the length of the distraction gap. Current clinical indications for DO include limb length discrepancy, congenital bone length deformity, large bone defects, and extremity reconstruction due to hypoplasia or limb salvage procedures. The risks of DO include soft tissue complications, relapse or improper correction, cost or resource-related challenges, and psychosocial stigmas surrounding long treatment durations and the necessity of wearing the distraction lengthening hardware. Future directions for DO include supplements to the bone regeneration process (such as growth factors and/or mechanical stimulation) or improvements to the distractor device itself (changes in material and/or the structure of the device itself). This review aims to offer a comprehensive summary of the indications, underlying biological mechanisms, and practical considerations when implementing the use of distraction osteogenesis in clinical practice.https://www.mdpi.com/2813-0464/3/4/32distraction osteogenesisbone regeneration |
| spellingShingle | Babapelumi Adejuyigbe Mohini Gharpure Charlotte F. Wahle Jennifer R. Kallini Distraction Osteogenesis: A Comprehensive Review Applied Biosciences distraction osteogenesis bone regeneration |
| title | Distraction Osteogenesis: A Comprehensive Review |
| title_full | Distraction Osteogenesis: A Comprehensive Review |
| title_fullStr | Distraction Osteogenesis: A Comprehensive Review |
| title_full_unstemmed | Distraction Osteogenesis: A Comprehensive Review |
| title_short | Distraction Osteogenesis: A Comprehensive Review |
| title_sort | distraction osteogenesis a comprehensive review |
| topic | distraction osteogenesis bone regeneration |
| url | https://www.mdpi.com/2813-0464/3/4/32 |
| work_keys_str_mv | AT babapelumiadejuyigbe distractionosteogenesisacomprehensivereview AT mohinigharpure distractionosteogenesisacomprehensivereview AT charlottefwahle distractionosteogenesisacomprehensivereview AT jenniferrkallini distractionosteogenesisacomprehensivereview |