ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma

ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is labeled with high mortality and tolerance to chemotherapy. Sorafenib has been the first‐line treatment option in HCC patients for past decades, while the therapeutic effect was limited in almost HCC patients. Methods In this study, we analyzed pu...

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Bibliographic Details
Main Authors: Ying Shi, Jin Shang, Yan Li, Deyuan Zhong, Zilong Zhang, Qinyan Yang, Chunyou Lai, Tianhang Feng, Yutong Yao, Xiaolun Huang
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
drug resistance
hepatocellular carcinoma
hypoxia
integrin
sorafenib
vascular mimicry
Online Access:https://doi.org/10.1002/cam4.5110
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