Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference
Corticomuscular coupling (CMC) can quantify the information interaction between the brain and muscles during motor control. However, current research regarding changes in CMC after stroke is inconsistent. To address this, this paper propose a novel use of <inline-formula> <tex-math notation...
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| Format: | Article |
| Language: | English |
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IEEE
2025-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/10982247/ |
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| author | Hui Chang Rong Xin Yixuan Sheng Zhiyong Wang Ruikai Cao Xianxian Yu Pu Wang Honghai Liu |
| author_facet | Hui Chang Rong Xin Yixuan Sheng Zhiyong Wang Ruikai Cao Xianxian Yu Pu Wang Honghai Liu |
| author_sort | Hui Chang |
| collection | DOAJ |
| description | Corticomuscular coupling (CMC) can quantify the information interaction between the brain and muscles during motor control. However, current research regarding changes in CMC after stroke is inconsistent. To address this, this paper propose a novel use of <inline-formula> <tex-math notation="LaTeX">$\textit {CMC}_{\textit {dif}}$ </tex-math></inline-formula> as an indicator to assess motor function after stroke. This indicator include <inline-formula> <tex-math notation="LaTeX">$\textit {WC}_{\textit {dif}}$ </tex-math></inline-formula>, derived from wavelet coherence analysis and <inline-formula> <tex-math notation="LaTeX">$\textit {TSE}_{\textit {dif}}$ </tex-math></inline-formula>, derived from transfer spectral entropy analysis. Twelve stroke patients and twelve healthy controls were included in this study, with an experimental paradigm of upper limb isokinetic push-pull movements. The results revealed that <inline-formula> <tex-math notation="LaTeX">$\textit {WC}_{\textit {dif}}$ </tex-math></inline-formula> were significantly higher in the stroke patient group compared to the healthy group. Moreover, the <inline-formula> <tex-math notation="LaTeX">$\textit {TSE}_{\textit {dif}}$ </tex-math></inline-formula> of stroke group is higher than healthy group on the efferent pathway, but no difference on the afferent pathway. Utilizing the validated <inline-formula> <tex-math notation="LaTeX">$\textit {CMC}_{\textit {dif}}$ </tex-math></inline-formula> indices, we developed a motor function assessment model that showed strong relation with clinical assessment outcomes (<inline-formula> <tex-math notation="LaTeX">${R}^{{2}}={0}.{873}$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">${p}={0}.{003}$ </tex-math></inline-formula>). These findings provide a new insight to understand the mechanisms underlying CMC changes after stroke. The combined use of linear and nonlinear indicators enhances the potential of CMC for clinical motor function assessment in stroke patients. |
| format | Article |
| id | doaj-art-a74d4425a4f54a08813d9e3753cce321 |
| institution | OA Journals |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-a74d4425a4f54a08813d9e3753cce3212025-08-20T01:50:29ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102025-01-01331817182610.1109/TNSRE.2025.356653310982247Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere DifferenceHui Chang0https://orcid.org/0000-0002-0454-7260Rong Xin1https://orcid.org/0000-0002-7935-1860Yixuan Sheng2https://orcid.org/0000-0003-1022-7690Zhiyong Wang3https://orcid.org/0000-0001-5546-6666Ruikai Cao4Xianxian Yu5Pu Wang6Honghai Liu7https://orcid.org/0000-0002-2880-4698The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaState Key Laboratory of Robotics and Systems, Harbin Institute of Technology at Shenzhen, Shenzhen, ChinaState Key Laboratory of Robotics and Systems, Harbin Institute of Technology at Shenzhen, Shenzhen, ChinaState Key Laboratory of Robotics and Systems, Harbin Institute of Technology at Shenzhen, Shenzhen, ChinaThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaCorticomuscular coupling (CMC) can quantify the information interaction between the brain and muscles during motor control. However, current research regarding changes in CMC after stroke is inconsistent. To address this, this paper propose a novel use of <inline-formula> <tex-math notation="LaTeX">$\textit {CMC}_{\textit {dif}}$ </tex-math></inline-formula> as an indicator to assess motor function after stroke. This indicator include <inline-formula> <tex-math notation="LaTeX">$\textit {WC}_{\textit {dif}}$ </tex-math></inline-formula>, derived from wavelet coherence analysis and <inline-formula> <tex-math notation="LaTeX">$\textit {TSE}_{\textit {dif}}$ </tex-math></inline-formula>, derived from transfer spectral entropy analysis. Twelve stroke patients and twelve healthy controls were included in this study, with an experimental paradigm of upper limb isokinetic push-pull movements. The results revealed that <inline-formula> <tex-math notation="LaTeX">$\textit {WC}_{\textit {dif}}$ </tex-math></inline-formula> were significantly higher in the stroke patient group compared to the healthy group. Moreover, the <inline-formula> <tex-math notation="LaTeX">$\textit {TSE}_{\textit {dif}}$ </tex-math></inline-formula> of stroke group is higher than healthy group on the efferent pathway, but no difference on the afferent pathway. Utilizing the validated <inline-formula> <tex-math notation="LaTeX">$\textit {CMC}_{\textit {dif}}$ </tex-math></inline-formula> indices, we developed a motor function assessment model that showed strong relation with clinical assessment outcomes (<inline-formula> <tex-math notation="LaTeX">${R}^{{2}}={0}.{873}$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">${p}={0}.{003}$ </tex-math></inline-formula>). These findings provide a new insight to understand the mechanisms underlying CMC changes after stroke. The combined use of linear and nonlinear indicators enhances the potential of CMC for clinical motor function assessment in stroke patients.https://ieeexplore.ieee.org/document/10982247/Motor function assessmentcortico-muscular couplingwavelet coherencetransfer spectrum entropy |
| spellingShingle | Hui Chang Rong Xin Yixuan Sheng Zhiyong Wang Ruikai Cao Xianxian Yu Pu Wang Honghai Liu Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference IEEE Transactions on Neural Systems and Rehabilitation Engineering Motor function assessment cortico-muscular coupling wavelet coherence transfer spectrum entropy |
| title | Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference |
| title_full | Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference |
| title_fullStr | Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference |
| title_full_unstemmed | Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference |
| title_short | Post-Stroke Corticomuscular Coupling Assessment Based on Bilateral Cerebral Hemisphere Difference |
| title_sort | post stroke corticomuscular coupling assessment based on bilateral cerebral hemisphere difference |
| topic | Motor function assessment cortico-muscular coupling wavelet coherence transfer spectrum entropy |
| url | https://ieeexplore.ieee.org/document/10982247/ |
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