Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of c...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2020/8832986 |
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| _version_ | 1832546896295493632 |
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| author | Alessandra Petrillo Noa Biran Sean Sadikot |
| author_facet | Alessandra Petrillo Noa Biran Sean Sadikot |
| author_sort | Alessandra Petrillo |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of care of ARDS, and current treatments at this time currently do not target the immunological mechanisms or pathways involved. Treatments involving this pathway should be further investigated as targeted treatment. We discuss a case of a patient with multiple myeloma who was hospitalized with drug-induced ARDS who had a rapid response to an anti-interleukin-6 monoclonal antibody. |
| format | Article |
| id | doaj-art-a74a78025090456fb7a4652a73963472 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-a74a78025090456fb7a4652a739634722025-02-03T06:46:55ZengWileyCase Reports in Critical Care2090-64202090-64392020-01-01202010.1155/2020/88329868832986Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress SyndromeAlessandra Petrillo0Noa Biran1Sean Sadikot2Hackensack University Medical Center, Hackensack, NJ, USAHackensack University Medical Center, Hackensack, NJ, USAHackensack University Medical Center, Hackensack, NJ, USAAcute respiratory distress syndrome (ARDS) is a disorder that involves the activation of alveolar macrophages triggering the innate immune system. The parenchymal lung injury seen in ARDS is a result of many proinflammatory elevations including interleukin-6. There remains no effective standard of care of ARDS, and current treatments at this time currently do not target the immunological mechanisms or pathways involved. Treatments involving this pathway should be further investigated as targeted treatment. We discuss a case of a patient with multiple myeloma who was hospitalized with drug-induced ARDS who had a rapid response to an anti-interleukin-6 monoclonal antibody.http://dx.doi.org/10.1155/2020/8832986 |
| spellingShingle | Alessandra Petrillo Noa Biran Sean Sadikot Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome Case Reports in Critical Care |
| title | Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome |
| title_full | Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome |
| title_fullStr | Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome |
| title_full_unstemmed | Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome |
| title_short | Use of Anti-Interleukin-6 Receptor Monoclonal Antibody in Drug-Induced Acute Respiratory Distress Syndrome |
| title_sort | use of anti interleukin 6 receptor monoclonal antibody in drug induced acute respiratory distress syndrome |
| url | http://dx.doi.org/10.1155/2020/8832986 |
| work_keys_str_mv | AT alessandrapetrillo useofantiinterleukin6receptormonoclonalantibodyindruginducedacuterespiratorydistresssyndrome AT noabiran useofantiinterleukin6receptormonoclonalantibodyindruginducedacuterespiratorydistresssyndrome AT seansadikot useofantiinterleukin6receptormonoclonalantibodyindruginducedacuterespiratorydistresssyndrome |