Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis
Selenium nanoparticles (SeNPs) were often used as growth and antioxidant capacity promoter. In this study, we found selenium nanoparticles (SeNPs) could improve the survival rate of Onychostoma macrolepis (O. macrolepis) fry as a feed additive after a challenged by Aeromonas hydrophila (A. hydrophil...
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Aquaculture and Fisheries |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468550X23000801 |
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| author | Chao Zhu Guofan Peng Jincan Li Yalong Deng Tianqi Jin Qimin Liu Heran Cao Zifang Wu Yuxuan Ma Zhenpeng Li Yang Wang Lijuan Zheng Xiangtong Yuan Lijun Zhang Fangxia Yang Hong Ji Wuzi Dong |
| author_facet | Chao Zhu Guofan Peng Jincan Li Yalong Deng Tianqi Jin Qimin Liu Heran Cao Zifang Wu Yuxuan Ma Zhenpeng Li Yang Wang Lijuan Zheng Xiangtong Yuan Lijun Zhang Fangxia Yang Hong Ji Wuzi Dong |
| author_sort | Chao Zhu |
| collection | DOAJ |
| description | Selenium nanoparticles (SeNPs) were often used as growth and antioxidant capacity promoter. In this study, we found selenium nanoparticles (SeNPs) could improve the survival rate of Onychostoma macrolepis (O. macrolepis) fry as a feed additive after a challenged by Aeromonas hydrophila (A. hydrophila). To further explore the mechanism of SeNPs against bacterial infection, we examined the changes before and after bacterial infection, and the results showed that large amounts of peroxide were produced under A. hydrophila infection in O. macrolepis fry, and then the excessive accumulation of peroxides led to a large amount of ferroptosis in the liver. Interestingly, we found supplementing 0.9 mg/kg biogenic SeNPs decreased MDA, iron content, and enhanced T-AOC levels in the liver of O. macrolepis fry after a challenged by Aeromonas hydrophila (P˂0.01). Especially, the diet with 0.9 mg/kg biogenic SeNPs could significantly increase the expression level of Glutathione peroxidase-4 (GPX4), nuclear factor erythroid2-related factor 2 (Nrf2), and Ferroportin 1 (FPN1) in the liver of O. macrolepis after infection with A. hydrophila. In summary, the results of this research suggested that the diet with 0.9 mg/kg biogenic SeNPs was an optimal additive dose to improve the survival rate of O. macrolepis fry by increasing antioxidant capacity and inhibiting ferroptosis, which sheds a new light on the mechanism of antibacterial infection in fish from the perspective of ferroptosis. |
| format | Article |
| id | doaj-art-a738bb9d745e4e1c8b02f8efbae3ff7d |
| institution | Kabale University |
| issn | 2468-550X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Aquaculture and Fisheries |
| spelling | doaj-art-a738bb9d745e4e1c8b02f8efbae3ff7d2025-02-09T05:00:50ZengKeAi Communications Co., Ltd.Aquaculture and Fisheries2468-550X2025-01-011013948Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosisChao Zhu0Guofan Peng1Jincan Li2Yalong Deng3Tianqi Jin4Qimin Liu5Heran Cao6Zifang Wu7Yuxuan Ma8Zhenpeng Li9Yang Wang10Lijuan Zheng11Xiangtong Yuan12Lijun Zhang13Fangxia Yang14Hong Ji15Wuzi Dong16College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaChina Selenium-enriched Industry Research Institute, Ankang, Shaanxi, 725000, ChinaCollege of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi, 712100, China; Corresponding author. College of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, 712100, China.Selenium nanoparticles (SeNPs) were often used as growth and antioxidant capacity promoter. In this study, we found selenium nanoparticles (SeNPs) could improve the survival rate of Onychostoma macrolepis (O. macrolepis) fry as a feed additive after a challenged by Aeromonas hydrophila (A. hydrophila). To further explore the mechanism of SeNPs against bacterial infection, we examined the changes before and after bacterial infection, and the results showed that large amounts of peroxide were produced under A. hydrophila infection in O. macrolepis fry, and then the excessive accumulation of peroxides led to a large amount of ferroptosis in the liver. Interestingly, we found supplementing 0.9 mg/kg biogenic SeNPs decreased MDA, iron content, and enhanced T-AOC levels in the liver of O. macrolepis fry after a challenged by Aeromonas hydrophila (P˂0.01). Especially, the diet with 0.9 mg/kg biogenic SeNPs could significantly increase the expression level of Glutathione peroxidase-4 (GPX4), nuclear factor erythroid2-related factor 2 (Nrf2), and Ferroportin 1 (FPN1) in the liver of O. macrolepis after infection with A. hydrophila. In summary, the results of this research suggested that the diet with 0.9 mg/kg biogenic SeNPs was an optimal additive dose to improve the survival rate of O. macrolepis fry by increasing antioxidant capacity and inhibiting ferroptosis, which sheds a new light on the mechanism of antibacterial infection in fish from the perspective of ferroptosis.http://www.sciencedirect.com/science/article/pii/S2468550X23000801Biogenic SeNPsFerroptosisO. macrolepisAnti-bacteria ability |
| spellingShingle | Chao Zhu Guofan Peng Jincan Li Yalong Deng Tianqi Jin Qimin Liu Heran Cao Zifang Wu Yuxuan Ma Zhenpeng Li Yang Wang Lijuan Zheng Xiangtong Yuan Lijun Zhang Fangxia Yang Hong Ji Wuzi Dong Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis Aquaculture and Fisheries Biogenic SeNPs Ferroptosis O. macrolepis Anti-bacteria ability |
| title | Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis |
| title_full | Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis |
| title_fullStr | Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis |
| title_full_unstemmed | Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis |
| title_short | Characterization of selenium nanoparticles extracted from Bacillus subtilis and its antibacterial effects in Onychostoma macrolepis: Insight into ferroptosis |
| title_sort | characterization of selenium nanoparticles extracted from bacillus subtilis and its antibacterial effects in onychostoma macrolepis insight into ferroptosis |
| topic | Biogenic SeNPs Ferroptosis O. macrolepis Anti-bacteria ability |
| url | http://www.sciencedirect.com/science/article/pii/S2468550X23000801 |
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