Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome
Background. A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS). Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown. We asse...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/7631804 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169823427821568 |
|---|---|
| author | Kai I. Cheang Sakita N. Sistrun Kelley S. Morel John E. Nestler |
| author_facet | Kai I. Cheang Sakita N. Sistrun Kelley S. Morel John E. Nestler |
| author_sort | Kai I. Cheang |
| collection | DOAJ |
| description | Background. A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS). Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown. We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS. Methods. Obese PCOS (n=16) and normal (n=15) women underwent 8 weeks of a hypocaloric diet. The Matsuda index, area under the curve DCI-IPG (AUCDCI-IPG), AUCinsulin, and AUCDCI-IPG/AUCinsulin were measured during a 2 hr OGTT at baseline and 8 weeks. Results. PCOS women had lower AUCDCI-IPG/AUCinsulin at baseline and a significant relationship between AUCDCI-IPG/AUCinsulin and Matsuda index (p=0.0003), which was not present in controls. Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, p=0.6281). Weight loss in PCOS women did not change the relationship between AUCDCI-IPG/AUCinsulin and Matsuda index (p=0.0100), and this relationship remained absent in control women. Conclusion. The association between AUCDCI-IPG/AUCinsulin and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss. DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity. |
| format | Article |
| id | doaj-art-a7372da4e83447d8b2f5c57cf3cf77c0 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a7372da4e83447d8b2f5c57cf3cf77c02025-08-20T02:20:38ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/76318047631804Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary SyndromeKai I. Cheang0Sakita N. Sistrun1Kelley S. Morel2John E. Nestler3Department of Pharmacotherapy & Outcomes Science, School of Pharmacy, Virginia Commonwealth University, P.O. Box 980533, Richmond, VA 23298-0533, USABionutrition Service, Center for Clinical and Translational Research, Virginia Commonwealth University, P.O. Box 980155, Richmond, VA 23298-0155, USACarilion Clinic Obstetrics & Gynecology, 102 Highland Ave, Suite 455, Roanoke, VA 24013, USAVirginia Commonwealth University Institute for Women’s Health, P.O. Box 980319, Richmond, VA 23298-0319, USABackground. A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS). Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown. We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS. Methods. Obese PCOS (n=16) and normal (n=15) women underwent 8 weeks of a hypocaloric diet. The Matsuda index, area under the curve DCI-IPG (AUCDCI-IPG), AUCinsulin, and AUCDCI-IPG/AUCinsulin were measured during a 2 hr OGTT at baseline and 8 weeks. Results. PCOS women had lower AUCDCI-IPG/AUCinsulin at baseline and a significant relationship between AUCDCI-IPG/AUCinsulin and Matsuda index (p=0.0003), which was not present in controls. Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, p=0.6281). Weight loss in PCOS women did not change the relationship between AUCDCI-IPG/AUCinsulin and Matsuda index (p=0.0100), and this relationship remained absent in control women. Conclusion. The association between AUCDCI-IPG/AUCinsulin and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss. DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity.http://dx.doi.org/10.1155/2016/7631804 |
| spellingShingle | Kai I. Cheang Sakita N. Sistrun Kelley S. Morel John E. Nestler Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome |
| title_full | Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome |
| title_fullStr | Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome |
| title_full_unstemmed | Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome |
| title_short | Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome |
| title_sort | effect on insulin stimulated release of d chiro inositol containing inositolphosphoglycan mediator during weight loss in obese women with and without polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2016/7631804 |
| work_keys_str_mv | AT kaiicheang effectoninsulinstimulatedreleaseofdchiroinositolcontaininginositolphosphoglycanmediatorduringweightlossinobesewomenwithandwithoutpolycysticovarysyndrome AT sakitansistrun effectoninsulinstimulatedreleaseofdchiroinositolcontaininginositolphosphoglycanmediatorduringweightlossinobesewomenwithandwithoutpolycysticovarysyndrome AT kelleysmorel effectoninsulinstimulatedreleaseofdchiroinositolcontaininginositolphosphoglycanmediatorduringweightlossinobesewomenwithandwithoutpolycysticovarysyndrome AT johnenestler effectoninsulinstimulatedreleaseofdchiroinositolcontaininginositolphosphoglycanmediatorduringweightlossinobesewomenwithandwithoutpolycysticovarysyndrome |