RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS
The purpose of this study was to analyze the short-term and 1-year long-term results of the treatment including radical surgery and intraoperative radiotherapy (IORT) in patients with primary (PRC) and recurrent rectal cancer (RRC). We retrospectively reviewed 68 patients (pts.) treated with the Int...
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2015-06-01
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| Series: | Кубанский научный медицинский вестник |
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| Online Access: | https://ksma.elpub.ru/jour/article/view/339 |
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| author | I. B. Uvarov M. V. Kazantseva S. N. Potemin I. N. Vasilenko V. B. Kaushansky |
| author_facet | I. B. Uvarov M. V. Kazantseva S. N. Potemin I. N. Vasilenko V. B. Kaushansky |
| author_sort | I. B. Uvarov |
| collection | DOAJ |
| description | The purpose of this study was to analyze the short-term and 1-year long-term results of the treatment including radical surgery and intraoperative radiotherapy (IORT) in patients with primary (PRC) and recurrent rectal cancer (RRC). We retrospectively reviewed 68 patients (pts.) treated with the Intrabeam Photon Radiosurgery System (PRS) following definitive resection of a locally advanced PRC or RRC. Gender distribution was 41 male and 27 female aged from 33 to 82 years (median 64.5). Stage II primary rectal cancer (PRC) was in 50 pts., stage III in 18 pts. RRC was found in 9 pts median follow-up after IORT was 9,6 months. Overall survival and disease free survival rate calculated using Kaplan-Meier analysis. A dose of 5.07Gy was prescribed to a depth of 1 cm (surface dose range was 9.4-17.0, median: 14.8 Gy). Median duration of IORT was 31.9 minutes (range: 15-36). Spheric applicators of 5 cm in diameter used in 40 cases and 4.5 cm - in 5 pts. No intraoperative or postoperative complications were attributed to IORT. Median discharge time after surgery was 17.7 days (range: 9-25). The 1-year overall survival rate was 90,1% (S.E.=4,9). The 1-year local recurrence free survival rate was 89,5% (S.E.=7,1). The 1-year distant metastasis free survival was 88,6% (S.E.=6,5). No cases of hydronephrosis or ureter fibrosis after IORT were documented. Fist experience suggests that Intrabeam PRS appears to be a safe technique for delivering IORT in rectal cancer patients. IORT with PRS marginally increased operative time, and did not appear to prolong hospitalization. |
| format | Article |
| id | doaj-art-a72eb9915f4448508a9b5960eeb6e833 |
| institution | Kabale University |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| publishDate | 2015-06-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj-art-a72eb9915f4448508a9b5960eeb6e8332025-08-20T03:57:13ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442015-06-013105110339RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTSI. B. Uvarov0M. V. Kazantseva1S. N. Potemin2I. N. Vasilenko3V. B. Kaushansky4State budget institution «Clinical cancer dispensary № 1»; Kuban state medical universityState budget institution «Clinical cancer dispensary № 1»State budget institution «Clinical cancer dispensary № 1»; Kuban state medical universityState budget institution «Clinical cancer dispensary № 1»State budget institution «Clinical cancer dispensary № 1»The purpose of this study was to analyze the short-term and 1-year long-term results of the treatment including radical surgery and intraoperative radiotherapy (IORT) in patients with primary (PRC) and recurrent rectal cancer (RRC). We retrospectively reviewed 68 patients (pts.) treated with the Intrabeam Photon Radiosurgery System (PRS) following definitive resection of a locally advanced PRC or RRC. Gender distribution was 41 male and 27 female aged from 33 to 82 years (median 64.5). Stage II primary rectal cancer (PRC) was in 50 pts., stage III in 18 pts. RRC was found in 9 pts median follow-up after IORT was 9,6 months. Overall survival and disease free survival rate calculated using Kaplan-Meier analysis. A dose of 5.07Gy was prescribed to a depth of 1 cm (surface dose range was 9.4-17.0, median: 14.8 Gy). Median duration of IORT was 31.9 minutes (range: 15-36). Spheric applicators of 5 cm in diameter used in 40 cases and 4.5 cm - in 5 pts. No intraoperative or postoperative complications were attributed to IORT. Median discharge time after surgery was 17.7 days (range: 9-25). The 1-year overall survival rate was 90,1% (S.E.=4,9). The 1-year local recurrence free survival rate was 89,5% (S.E.=7,1). The 1-year distant metastasis free survival was 88,6% (S.E.=6,5). No cases of hydronephrosis or ureter fibrosis after IORT were documented. Fist experience suggests that Intrabeam PRS appears to be a safe technique for delivering IORT in rectal cancer patients. IORT with PRS marginally increased operative time, and did not appear to prolong hospitalization.https://ksma.elpub.ru/jour/article/view/339колоректальный ракинтраоперационная лучевая терапияместный рецидивcolorectal cancerintraoperative radiation therapylocal disease recurrence |
| spellingShingle | I. B. Uvarov M. V. Kazantseva S. N. Potemin I. N. Vasilenko V. B. Kaushansky RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS Кубанский научный медицинский вестник колоректальный рак интраоперационная лучевая терапия местный рецидив colorectal cancer intraoperative radiation therapy local disease recurrence |
| title | RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS |
| title_full | RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS |
| title_fullStr | RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS |
| title_full_unstemmed | RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS |
| title_short | RADICAL SURGERY AND INTRAOPERATIVE RADIOTHERAPY WITH THE PHOTON RADIOSURGERY SYSTEM IN RECTAL CANCER: RETROSPECTIVE REVIEW OF 68 PATIENTS |
| title_sort | radical surgery and intraoperative radiotherapy with the photon radiosurgery system in rectal cancer retrospective review of 68 patients |
| topic | колоректальный рак интраоперационная лучевая терапия местный рецидив colorectal cancer intraoperative radiation therapy local disease recurrence |
| url | https://ksma.elpub.ru/jour/article/view/339 |
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