Association between peripheral and coronary microvascular function and the impact of myocardial bridging
Abstract The reactive hyperemia index (RHI) is a marker of peripheral microvascular function influenced by both endothelium‐dependent and independent mechanisms. Myocardial bridging (MB) may impact coronary microvascular function, but its effect on the relationship between RHI and coronary microvasc...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70340 |
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| author | Takumi Toya Shotaro Yoshida Kazuhiko Kuinose Shun Akai Tsukasa Urushima Kaoru Naito Masanori Oobori Yusei Nakashima Akira Miyauchi Yuji Nagatomo Takeshi Adachi |
| author_facet | Takumi Toya Shotaro Yoshida Kazuhiko Kuinose Shun Akai Tsukasa Urushima Kaoru Naito Masanori Oobori Yusei Nakashima Akira Miyauchi Yuji Nagatomo Takeshi Adachi |
| author_sort | Takumi Toya |
| collection | DOAJ |
| description | Abstract The reactive hyperemia index (RHI) is a marker of peripheral microvascular function influenced by both endothelium‐dependent and independent mechanisms. Myocardial bridging (MB) may impact coronary microvascular function, but its effect on the relationship between RHI and coronary microvascular function remains unclear. In this cross‐sectional study, 38 patients underwent noninvasive RHI assessment alongside invasive coronary microvascular function testing. MB was identified via coronary angiography, while endothelium‐dependent and independent coronary microvascular function were evaluated using coronary flow reserve in response to intracoronary administration of acetylcholine and microvascular resistance reserve in response to intravenous administration of adenosine, respectively. Among 38 patients (mean age: 59 years, 34% male), 14 had MB. RHI correlated with an index of endothelium‐independent coronary microvascular function (r = 0.34, p = 0.04), whereas it did not correlate with that of endothelium‐dependent function. This correlation persisted in patients without MB (r = 0.54, p = 0.01) but was lost in those with MB (p = 0.83). RHI is associated with endothelium‐independent coronary microvascular function, but MB disrupts this relationship, suggesting a local impact on coronary microvascular physiology. |
| format | Article |
| id | doaj-art-a727e236f5ca4633b8f1b8eeafdeafa6 |
| institution | OA Journals |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-a727e236f5ca4633b8f1b8eeafdeafa62025-08-20T02:20:25ZengWileyPhysiological Reports2051-817X2025-04-01138n/an/a10.14814/phy2.70340Association between peripheral and coronary microvascular function and the impact of myocardial bridgingTakumi Toya0Shotaro Yoshida1Kazuhiko Kuinose2Shun Akai3Tsukasa Urushima4Kaoru Naito5Masanori Oobori6Yusei Nakashima7Akira Miyauchi8Yuji Nagatomo9Takeshi Adachi10Division of Cardiology National Defense Medical College Saitama JapanSchool of Medicine National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanDivision of Cardiology National Defense Medical College Saitama JapanAbstract The reactive hyperemia index (RHI) is a marker of peripheral microvascular function influenced by both endothelium‐dependent and independent mechanisms. Myocardial bridging (MB) may impact coronary microvascular function, but its effect on the relationship between RHI and coronary microvascular function remains unclear. In this cross‐sectional study, 38 patients underwent noninvasive RHI assessment alongside invasive coronary microvascular function testing. MB was identified via coronary angiography, while endothelium‐dependent and independent coronary microvascular function were evaluated using coronary flow reserve in response to intracoronary administration of acetylcholine and microvascular resistance reserve in response to intravenous administration of adenosine, respectively. Among 38 patients (mean age: 59 years, 34% male), 14 had MB. RHI correlated with an index of endothelium‐independent coronary microvascular function (r = 0.34, p = 0.04), whereas it did not correlate with that of endothelium‐dependent function. This correlation persisted in patients without MB (r = 0.54, p = 0.01) but was lost in those with MB (p = 0.83). RHI is associated with endothelium‐independent coronary microvascular function, but MB disrupts this relationship, suggesting a local impact on coronary microvascular physiology.https://doi.org/10.14814/phy2.70340coronary microvascular dysfunctionmyocardial bridgingperipheral microvascular dysfunction |
| spellingShingle | Takumi Toya Shotaro Yoshida Kazuhiko Kuinose Shun Akai Tsukasa Urushima Kaoru Naito Masanori Oobori Yusei Nakashima Akira Miyauchi Yuji Nagatomo Takeshi Adachi Association between peripheral and coronary microvascular function and the impact of myocardial bridging Physiological Reports coronary microvascular dysfunction myocardial bridging peripheral microvascular dysfunction |
| title | Association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| title_full | Association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| title_fullStr | Association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| title_full_unstemmed | Association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| title_short | Association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| title_sort | association between peripheral and coronary microvascular function and the impact of myocardial bridging |
| topic | coronary microvascular dysfunction myocardial bridging peripheral microvascular dysfunction |
| url | https://doi.org/10.14814/phy2.70340 |
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