Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis
Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/471463 |
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| author | Bokun Lv Jie Huang Haining Yuan Wenying Yan Guang Hu Jian Wang |
| author_facet | Bokun Lv Jie Huang Haining Yuan Wenying Yan Guang Hu Jian Wang |
| author_sort | Bokun Lv |
| collection | DOAJ |
| description | Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis. The TNF-α test showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76, Q* = 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89, Q* = 0.87). We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-α is also a valuable marker in the diagnosis of NS. |
| format | Article |
| id | doaj-art-a718353bc29545dca7ea11d8c2a99ec0 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a718353bc29545dca7ea11d8c2a99ec02025-08-20T03:38:49ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/471463471463Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-AnalysisBokun Lv0Jie Huang1Haining Yuan2Wenying Yan3Guang Hu4Jian Wang5Systems Sepsis Team, Soochow University Affiliated Children’s Hospital, Suzhou 215003, ChinaSystems Sepsis Team, Soochow University Affiliated Children’s Hospital, Suzhou 215003, ChinaSystems Sepsis Team, Soochow University Affiliated Children’s Hospital, Suzhou 215003, ChinaSuzhou Zhengxing Translational Biomedical Informatics Ltd., Taicang 215400, ChinaCenter for Systems Biology, Soochow University, Suzhou 215006, ChinaSystems Sepsis Team, Soochow University Affiliated Children’s Hospital, Suzhou 215003, ChinaNeonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis. The TNF-α test showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76, Q* = 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89, Q* = 0.87). We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-α is also a valuable marker in the diagnosis of NS.http://dx.doi.org/10.1155/2014/471463 |
| spellingShingle | Bokun Lv Jie Huang Haining Yuan Wenying Yan Guang Hu Jian Wang Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis The Scientific World Journal |
| title | Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis |
| title_full | Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis |
| title_fullStr | Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis |
| title_full_unstemmed | Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis |
| title_short | Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis |
| title_sort | tumor necrosis factor α as a diagnostic marker for neonatal sepsis a meta analysis |
| url | http://dx.doi.org/10.1155/2014/471463 |
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