Biochemical Status of Beta-Thalassemia Major Patients in Erbil City
Background and objectives: β -thalassemia major patient is one of the hereditary hemolytic diseases, which can cause many hematological and biochemical changes in the affected patient. And these changes can happen even when the patient is treated adequately. The objective was to study biochemical c...
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College Of Dentistry Hawler Medical University
2018-06-01
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| Series: | Erbil Dental Journal |
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| Online Access: | https://edj.hmu.edu.krd/index.php/journal/article/view/20 |
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| author | Omar Surchi Sarkawt Ali |
| author_facet | Omar Surchi Sarkawt Ali |
| author_sort | Omar Surchi |
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Background and objectives: β -thalassemia major patient is one of the hereditary hemolytic diseases, which can cause many hematological and biochemical changes in the affected patient. And these changes can happen even when the patient is treated adequately. The objective was to study biochemical changes in the level of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 in patients with β- thalassemia major and to compare it with control subjects.
Patients and method: In this research 40 patients with beta thalassemia major, 20 Female and 20 Male (age ranged from 10 to 38 years), and 40 control subjects 20 Female and 20 Male (age ranged from 9 to 33 years) were studied. Measurement of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 were done by the researcher for both cases and control groups.
Results: Serum Ferritin and Iron were higher significantly in all thalassemic patients (P< 0.001), this increment was proportional with increasing number of units of blood transfusion and aging. Mean serum Hepcidin, PTH, Osteocalcin and IL6 were significantly lower in thalassemic patients in contrast to the control subjects (P< 0.001). Reduction in S-PTH was proportional to increasing number of blood transfusion and aging.
Conclusion: Our study demonstrates that in B-thalassemia major patients Serum Ferritin and Iron were increased proportionally with increasing age and number of units of blood transfusion. Mean serum PTH, osteocalcin, hepcidin, and IL-6 were reduced, but mean serum calcium was remained normal.
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| format | Article |
| id | doaj-art-a71743a858cd46aab4f7d2489d4ba7cb |
| institution | Kabale University |
| issn | 2523-6172 2616-4795 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | College Of Dentistry Hawler Medical University |
| record_format | Article |
| series | Erbil Dental Journal |
| spelling | doaj-art-a71743a858cd46aab4f7d2489d4ba7cb2025-02-10T20:48:56ZengCollege Of Dentistry Hawler Medical UniversityErbil Dental Journal2523-61722616-47952018-06-0111Biochemical Status of Beta-Thalassemia Major Patients in Erbil CityOmar Surchi0Sarkawt Ali1College of Medicine, Hawler Medical universityMaxillofacial Department, College of Dentistry, Hawler Medical University Background and objectives: β -thalassemia major patient is one of the hereditary hemolytic diseases, which can cause many hematological and biochemical changes in the affected patient. And these changes can happen even when the patient is treated adequately. The objective was to study biochemical changes in the level of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 in patients with β- thalassemia major and to compare it with control subjects. Patients and method: In this research 40 patients with beta thalassemia major, 20 Female and 20 Male (age ranged from 10 to 38 years), and 40 control subjects 20 Female and 20 Male (age ranged from 9 to 33 years) were studied. Measurement of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 were done by the researcher for both cases and control groups. Results: Serum Ferritin and Iron were higher significantly in all thalassemic patients (P< 0.001), this increment was proportional with increasing number of units of blood transfusion and aging. Mean serum Hepcidin, PTH, Osteocalcin and IL6 were significantly lower in thalassemic patients in contrast to the control subjects (P< 0.001). Reduction in S-PTH was proportional to increasing number of blood transfusion and aging. Conclusion: Our study demonstrates that in B-thalassemia major patients Serum Ferritin and Iron were increased proportionally with increasing age and number of units of blood transfusion. Mean serum PTH, osteocalcin, hepcidin, and IL-6 were reduced, but mean serum calcium was remained normal. https://edj.hmu.edu.krd/index.php/journal/article/view/20β- thalassemiaSerum |
| spellingShingle | Omar Surchi Sarkawt Ali Biochemical Status of Beta-Thalassemia Major Patients in Erbil City Erbil Dental Journal β- thalassemia Serum |
| title | Biochemical Status of Beta-Thalassemia Major Patients in Erbil City |
| title_full | Biochemical Status of Beta-Thalassemia Major Patients in Erbil City |
| title_fullStr | Biochemical Status of Beta-Thalassemia Major Patients in Erbil City |
| title_full_unstemmed | Biochemical Status of Beta-Thalassemia Major Patients in Erbil City |
| title_short | Biochemical Status of Beta-Thalassemia Major Patients in Erbil City |
| title_sort | biochemical status of beta thalassemia major patients in erbil city |
| topic | β- thalassemia Serum |
| url | https://edj.hmu.edu.krd/index.php/journal/article/view/20 |
| work_keys_str_mv | AT omarsurchi biochemicalstatusofbetathalassemiamajorpatientsinerbilcity AT sarkawtali biochemicalstatusofbetathalassemiamajorpatientsinerbilcity |