Acral lentiginous melanoma with subsequent spontaneous vitiligo vulgaris: a case report and literature review
Acral lentiginous melanoma (ALM) is an infrequent and often missed subtype of melanoma. Its association with spontaneous vitiligo vulgaris is an exceedingly rare condition. The current study presents a rare case of ALM with spontaneous vitiligo vulgaris after complete resection of the ALM. An 84-ye...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2025-04-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/dr/article/view/10125 |
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| Summary: | Acral lentiginous melanoma (ALM) is an infrequent and often missed subtype of melanoma. Its association with spontaneous vitiligo vulgaris is an exceedingly rare condition. The current study presents a rare case of ALM with spontaneous vitiligo vulgaris after complete resection of the ALM. An 84-year-old male patient presented with multiple white skin lesions on the scalp, neck, trunk, and upper and lower limbs for a three-month duration. One year prior, a diagnosis of ALM was confirmed on histopathological examination with a pathological stage of T4bNxMx. The patient did not receive any treatment until the time of presentation, apart from the surgical removal of the primary tumor. No treatment was advised for the patient’s vitiligo vulgaris; only observation was recommended. Clinical diagnosis of vitiligo vulgaris was made with the association of ALM. In the literature review, only several case reports of vitiligo were attributed to ALM, especially without the use of immunotherapeutic agents. Melanoma represents a notably immunogenic malignancy, provoking both humoral and cellular responses from the immune system directed against cytoplasmic and membrane antigens of melanocytes. There is a suggestion that normal melanocytes might function as neutral observers and become targets of immune responses directed against melanoma cells, leading to melanoma-associated vitiligo. It occurs more commonly as a consequence of immunologic-based therapeutic interventions or after metastatic melanoma; however, the occurrence of spontaneous vitiligo vulgaris several months following complete surgical removal of ALM is possible.
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| ISSN: | 2036-7392 2036-7406 |