Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic bone in connective tissue, such as tendon, muscle, ligament and fascia (Kaplan et al, 2024). The prevalence is approximately one in 2.5 million births, with over 2,500 cases...
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Springer Nature
2024-12-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s44321-024-00180-5 |
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| author | Qiwen Li Quan Yuan |
| author_facet | Qiwen Li Quan Yuan |
| author_sort | Qiwen Li |
| collection | DOAJ |
| description | Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic bone in connective tissue, such as tendon, muscle, ligament and fascia (Kaplan et al, 2024). The prevalence is approximately one in 2.5 million births, with over 2,500 cases diagnosed globally. Although rare, FOP is a severe and life-limiting condition with no current cure. Due to heterotopic bone formation in various organs, patients experience intense pain, restricted mobility, difficulty with eating and speaking, hearing loss, scoliosis, and impaired pulmonary function. The average lifespan for individuals with FOP is around 40 years. Therefore, studying the pathological mechanism and developing efficient drugs for FOP are highly demanding. In this issue of EMBO Molecular Medicine, Zhao et al, introduce bone morphogenetic protein 9 (BMP9) as a potential therapeutic target for FOP (Zhao et al, 2024). |
| format | Article |
| id | doaj-art-a70ee5c6166b4513a6fce4da53cd5e94 |
| institution | Kabale University |
| issn | 1757-4684 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-a70ee5c6166b4513a6fce4da53cd5e942025-01-19T12:34:39ZengSpringer NatureEMBO Molecular Medicine1757-46842024-12-011711210.1038/s44321-024-00180-5Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressivaQiwen Li0Quan Yuan1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityFibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic bone in connective tissue, such as tendon, muscle, ligament and fascia (Kaplan et al, 2024). The prevalence is approximately one in 2.5 million births, with over 2,500 cases diagnosed globally. Although rare, FOP is a severe and life-limiting condition with no current cure. Due to heterotopic bone formation in various organs, patients experience intense pain, restricted mobility, difficulty with eating and speaking, hearing loss, scoliosis, and impaired pulmonary function. The average lifespan for individuals with FOP is around 40 years. Therefore, studying the pathological mechanism and developing efficient drugs for FOP are highly demanding. In this issue of EMBO Molecular Medicine, Zhao et al, introduce bone morphogenetic protein 9 (BMP9) as a potential therapeutic target for FOP (Zhao et al, 2024).https://doi.org/10.1038/s44321-024-00180-5 |
| spellingShingle | Qiwen Li Quan Yuan Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva EMBO Molecular Medicine |
| title | Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva |
| title_full | Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva |
| title_fullStr | Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva |
| title_full_unstemmed | Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva |
| title_short | Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva |
| title_sort | targeting to bmp9 to restrain flare up of fibrodysplasia ossificans progressiva |
| url | https://doi.org/10.1038/s44321-024-00180-5 |
| work_keys_str_mv | AT qiwenli targetingtobmp9torestrainflareupoffibrodysplasiaossificansprogressiva AT quanyuan targetingtobmp9torestrainflareupoffibrodysplasiaossificansprogressiva |