Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index
Abstract Background Obesity is a global health issue which has been widely accepted as an aging related pathogenesis. α-Klotho is a protein involved in aging process, mineral metabolism, insulin sensitivity, and the pathogenesis of various age-related diseases. Adiposity correlates with lower solubl...
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BMC
2025-04-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02541-6 |
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| author | Rui Du Xiaoyan Tang Lei Guan Yuchen Lai Huijuan Xiang Wei Huang |
| author_facet | Rui Du Xiaoyan Tang Lei Guan Yuchen Lai Huijuan Xiang Wei Huang |
| author_sort | Rui Du |
| collection | DOAJ |
| description | Abstract Background Obesity is a global health issue which has been widely accepted as an aging related pathogenesis. α-Klotho is a protein involved in aging process, mineral metabolism, insulin sensitivity, and the pathogenesis of various age-related diseases. Adiposity correlates with lower soluble α-Klotho, but the role of fat distribution and inflammation remains unclear. The body roundness index (BRI) refines central adiposity assessment beyond BMI. Herein, We aimed to investigate the relationship of BRI, inflammation and serum level of soluble α-Klotho. Methods We conducted a cross-sectional analysis of 9,958 U.S. adults (40–79 years) from the 2007–2016 NHANES. We examined association between BRI and serum α-Klotho (SαKl) levels, controlling for demographic, socioeconomic, lifestyle, and clinical factors. We also assessed whether inflammatory markers mediated the BRI–SαKl relationship. Results BRI was inversely associated with SαKl levels (P < 0.05). A significant sex interaction was found (P < 0.001), while BRI was positively correlated with multiple proinflammatory markers, which were all inversely related to SαKl levels. Mediation analyses showed inflammatory markers accounted for 20.5% (WBC), 18.0% (neutrophils), and 12.3% (platelets) of the BRI–SαKl association. Conclusion More severe central adiposity measured by BRI was related to lower SαKl, which may partly be attributed to inflammation. These findings underscore the importance of fat distribution and inflammation in obesity-related aging and may guide interventions to preserve SαKl levels. Longitudinal studies are needed to confirm causality and inform future strategies. |
| format | Article |
| id | doaj-art-a70dbb80576447599f5b5b456e44754d |
| institution | DOAJ |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-a70dbb80576447599f5b5b456e44754d2025-08-20T03:06:52ZengBMCLipids in Health and Disease1476-511X2025-04-0124111210.1186/s12944-025-02541-6Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness indexRui Du0Xiaoyan Tang1Lei Guan2Yuchen Lai3Huijuan Xiang4Wei Huang5Department of Ultrasound, General Hospital of Central Theater CommandDepartment of Cardiology, General Hospital of Central Theater CommandDepartment of Cardiology, General Hospital of Central Theater CommandSchool of Medicine, Wuhan University of Science and TechnologyDepartment of Ultrasound, General Hospital of Central Theater CommandDepartment of Cardiology, General Hospital of Central Theater CommandAbstract Background Obesity is a global health issue which has been widely accepted as an aging related pathogenesis. α-Klotho is a protein involved in aging process, mineral metabolism, insulin sensitivity, and the pathogenesis of various age-related diseases. Adiposity correlates with lower soluble α-Klotho, but the role of fat distribution and inflammation remains unclear. The body roundness index (BRI) refines central adiposity assessment beyond BMI. Herein, We aimed to investigate the relationship of BRI, inflammation and serum level of soluble α-Klotho. Methods We conducted a cross-sectional analysis of 9,958 U.S. adults (40–79 years) from the 2007–2016 NHANES. We examined association between BRI and serum α-Klotho (SαKl) levels, controlling for demographic, socioeconomic, lifestyle, and clinical factors. We also assessed whether inflammatory markers mediated the BRI–SαKl relationship. Results BRI was inversely associated with SαKl levels (P < 0.05). A significant sex interaction was found (P < 0.001), while BRI was positively correlated with multiple proinflammatory markers, which were all inversely related to SαKl levels. Mediation analyses showed inflammatory markers accounted for 20.5% (WBC), 18.0% (neutrophils), and 12.3% (platelets) of the BRI–SαKl association. Conclusion More severe central adiposity measured by BRI was related to lower SαKl, which may partly be attributed to inflammation. These findings underscore the importance of fat distribution and inflammation in obesity-related aging and may guide interventions to preserve SαKl levels. Longitudinal studies are needed to confirm causality and inform future strategies.https://doi.org/10.1186/s12944-025-02541-6α−KlothoAgingObesityBody roundness indexNHANES |
| spellingShingle | Rui Du Xiaoyan Tang Lei Guan Yuchen Lai Huijuan Xiang Wei Huang Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index Lipids in Health and Disease α−Klotho Aging Obesity Body roundness index NHANES |
| title | Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| title_full | Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| title_fullStr | Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| title_full_unstemmed | Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| title_short | Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| title_sort | central adiposity and α klotho inflammatory mechanisms underlying aging biomarkers related to body roundness index |
| topic | α−Klotho Aging Obesity Body roundness index NHANES |
| url | https://doi.org/10.1186/s12944-025-02541-6 |
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