Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city
Background and objective: The aims of the present research were to study the clinicopathological features of adult classical Hodgkin lymphoma (cHL) in Hawler city and to evaluate the significance of immunohistochemical expression of CD68 positive tumor associated macrophage in the tumor microenviron...
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| Format: | Article |
| Language: | English |
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Hawler Medical University
2025-04-01
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| Series: | Zanco Journal of Medical Sciences |
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| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/1045 |
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| author | Tenya Tariq Abdulhameed Salah Abubakir Ali Amin Aziz Bakir |
| author_facet | Tenya Tariq Abdulhameed Salah Abubakir Ali Amin Aziz Bakir |
| author_sort | Tenya Tariq Abdulhameed |
| collection | DOAJ |
| description | Background and objective: The aims of the present research were to study the clinicopathological features of adult classical Hodgkin lymphoma (cHL) in Hawler city and to evaluate the significance of immunohistochemical expression of CD68 positive tumor associated macrophage in the tumor microenvironment as a marker for prediction of malignant progression.
Methods: This is a retrospective cross-sectional study carried out in Rizgary Teaching Hospital and Nanakaly Hospital in Hawler city –Iraq in which 110cases of cHL patients were enrolled from January 2015 to July 2022.Clinical data were obtained from the hospital’s medical records. All specimens were revised for histopathological and immunohistochemical diagnosis of CD15 and CD30 followed by staining with CD68 using IHC.
Results: The IHC showed 56.36% of cases expressed intermediate staining score for CD68 immune marker whereas 27.27% expressed high staining score. A positive association was found between staging of the cases and CD68 immune expressions.
Conclusion: Positive CD68by immunohistochemical analysis on TAM have diagnostic significance, its overexpression may predict cancer progression. |
| format | Article |
| id | doaj-art-a70d983d00994ef7a91637a4ac29632c |
| institution | DOAJ |
| issn | 1995-5588 1995-5596 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj-art-a70d983d00994ef7a91637a4ac29632c2025-08-20T03:15:04ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962025-04-0129111011710.15218/zjms.2025.012Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler cityTenya Tariq Abdulhameed0Salah Abubakir Ali1Amin Aziz Bakir2Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq.Background and objective: The aims of the present research were to study the clinicopathological features of adult classical Hodgkin lymphoma (cHL) in Hawler city and to evaluate the significance of immunohistochemical expression of CD68 positive tumor associated macrophage in the tumor microenvironment as a marker for prediction of malignant progression. Methods: This is a retrospective cross-sectional study carried out in Rizgary Teaching Hospital and Nanakaly Hospital in Hawler city –Iraq in which 110cases of cHL patients were enrolled from January 2015 to July 2022.Clinical data were obtained from the hospital’s medical records. All specimens were revised for histopathological and immunohistochemical diagnosis of CD15 and CD30 followed by staining with CD68 using IHC. Results: The IHC showed 56.36% of cases expressed intermediate staining score for CD68 immune marker whereas 27.27% expressed high staining score. A positive association was found between staging of the cases and CD68 immune expressions. Conclusion: Positive CD68by immunohistochemical analysis on TAM have diagnostic significance, its overexpression may predict cancer progression.https://zjms.hmu.edu.krd/index.php/zjms/article/view/1045cd68classical hodgkin’s lymphoma (chl)tumor associated macrophage (tam) |
| spellingShingle | Tenya Tariq Abdulhameed Salah Abubakir Ali Amin Aziz Bakir Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city Zanco Journal of Medical Sciences cd68 classical hodgkin’s lymphoma (chl) tumor associated macrophage (tam) |
| title | Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city |
| title_full | Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city |
| title_fullStr | Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city |
| title_full_unstemmed | Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city |
| title_short | Clinicopathological value of tumor-associated macrophages in adult classical Hodgkin lymphoma in Hawler city |
| title_sort | clinicopathological value of tumor associated macrophages in adult classical hodgkin lymphoma in hawler city |
| topic | cd68 classical hodgkin’s lymphoma (chl) tumor associated macrophage (tam) |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/1045 |
| work_keys_str_mv | AT tenyatariqabdulhameed clinicopathologicalvalueoftumorassociatedmacrophagesinadultclassicalhodgkinlymphomainhawlercity AT salahabubakirali clinicopathologicalvalueoftumorassociatedmacrophagesinadultclassicalhodgkinlymphomainhawlercity AT aminazizbakir clinicopathologicalvalueoftumorassociatedmacrophagesinadultclassicalhodgkinlymphomainhawlercity |