CAR-T therapy: pioneering a new era in the treatment of autoimmune diseases

CAR-T therapy: pioneering a new era in the treatment of autoimmune diseases

CAR-T therapy, an innovative immunotherapeutic approach, genetically modifies T cells to express CARs, enabling targeted destruction of specific antigen-expressing cells. Initially developed for oncology, CAR-T therapy has shown significant potential in treating autoimmune diseases. By targeting CD1...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yuanhao Wu, Luyao Han, Yu Wang, Mengjiao Gu, Yunuo Wang, Jingyue Gao, Hanjing Huang, Chen Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	chimeric antigen receptor T-cell therapy CAR (chimeric antigen receptor) SLE - systemic lupus erythematosus autoimmune diseases adverse (side) effects
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1625166/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Chimeric Autoantibody Receptor- and/or Peptide-MHC-Based CAR Therapies for Targeted Elimination of Antigen-Specific B or T Cells in Hypersensitivity Disorders Such as Allergies and Autoimmune Diseases
by: Isidora Protić-Rosić, et al.
Published: (2025-05-01)

CAR-T: from bench to bedside
by: M. О. Popova, et al.
Published: (2024-09-01)

CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives
by: Martyna Kania, et al.
Published: (2025-05-01)

A new therapeutic pathway in autoimmune diseases: chimeric antigen receptor T cells (CAR-T) targeting specific cell subtypes or antigen-specific B lymphocytes—a brief review
by: María Fernanda Segovia, et al.
Published: (2025-03-01)

Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases
by: Mingwei Jiang, et al.
Published: (2025-12-01)

Expanding the Horizons of CAR-T Cell Therapy: A Review of Therapeutic Targets Across Diverse Diseases
by: Alejandrina Hernández-López, et al.
Published: (2025-01-01)

Study of the suppression of a tumor growth expressing a carcinoembryonic antigen with a new high-tech drug carplasmin (CAR-T therapy) in Balb/c nude mice
by: V. K. Bozhenko, et al.
Published: (2023-04-01)

Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)
by: Eugenio Galli, et al.
Published: (2021-10-01)

Future perspectives on novel CAR-T therapeutics beyond CD19 and BCMA in onco-hematology
by: Alina Ershova, et al.
Published: (2025-07-01)

Chimeric Antigen Receptor T-cell therapy in systemic autoimmune rheumatic diseases: current insights and future prospects
by: Bong-Woo Lee, et al.
Published: (2025-07-01)

Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024Keypoints
by: Bastian Engel, et al.
Published: (2025-02-01)

Tandem CAR-T cell therapy: recent advances and current challenges
by: Sara Gómez-Melero, et al.
Published: (2025-02-01)

Unleashing the power of CAR-M therapy in solid tumors: a comprehensive review
by: Ahsen Morva, et al.
Published: (2025-06-01)

CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives
by: Jincai Zhou, et al.
Published: (2024-12-01)

New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
by: Yuanyuan Yang, et al.
Published: (2024-11-01)

Strategies to overcome tumour relapse caused by antigen escape after CAR T therapy
by: Yufei Lu, et al.
Published: (2025-04-01)

Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells
by: Yang Liu, et al.
Published: (2025-01-01)

Efficacy and safety of CD19 combined with CD22 or CD20 chimeric antigen receptor T-cell therapy for hematological malignancies
by: Xiaoshuang Yuan, et al.
Published: (2025-05-01)

CAR-T cell therapy for hepatocellular carcinoma: current trends and challenges
by: Yexin Zhou, et al.
Published: (2024-11-01)

Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation
by: Pablo Gonzalez-Garcia, et al.
Published: (2025-07-01)

Outcomes with bridging radiation therapy prior to chimeric antigen receptor T-cell therapy in patients with aggressive large B-cell lymphomas
by: Gohar S. Manzar, et al.
Published: (2025-01-01)

The use of T-cells with chimeric antigen receptor (CAR-T) in combination with chemotherapy and radiotherapy for the treatment of solid tumors
by: M. R. Khaliulin, et al.
Published: (2024-04-01)

CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy
by: Trevor R. Baybutt, et al.
Published: (2024-12-01)

Serum ferritin as a prognostic biomarker in CAR-T therapy for multiple myeloma: A meta-analysis
by: Jing Cheng, et al.
Published: (2025-03-01)

CAR‐NK, a Splendid Strategy for Cancer, Especially for Gynecologic Tumor
by: Yisen Cao, et al.
Published: (2025-06-01)

From lab to lifesaver: the rise of CAR T-cell therapy in oncology
by: Shriyash S. Jangavali, et al.
Published: (2025-05-01)

The clinical landscape of CAR NK cells
by: Lasse Vedel Jørgensen, et al.
Published: (2025-03-01)

Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells
by: Kelly T. Kennewick, et al.
Published: (2024-06-01)

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice
by: Daniel Goyco Vera, et al.
Published: (2024-12-01)

Direct visualization of chimeric antigen receptors on primary human T cells using dSTORM super-resolution microscopy
by: Leon Gehrke, et al.
Published: (2025-08-01)

Does a natural killer need a CAR?
by: Kangbo Wang, et al.
Published: (2025-06-01)

Co-expression of a truncated TGFβ receptor II in c-Met CAR T cells enhances antitumor activity against lung adenocarcinoma
by: Chao Su, et al.
Published: (2025-08-01)

Editorial: Immunotherapy resistance and advancing adaptive cell therapeutics
by: Luciana Rodrigues Carvalho Barros, et al.
Published: (2025-06-01)

Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
by: Jing Ma, et al.
Published: (2025-07-01)

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways
by: Alexander Mazein, et al.
Published: (2024-12-01)

Diverse potential of chimeric antigen receptor‐engineered cell therapy: Beyond cancer
by: Lvying Wu, et al.
Published: (2025-04-01)

CAR-macrophages targets CD26 to eliminate chronic myeloid leukemia stem cells
by: Jiang Guoyun, et al.
Published: (2025-02-01)

Hepatic T cell lymphoma after chimeric antigen receptor T cell therapy for myeloma
by: Joshua Mehr, et al.
Published: (2024-12-01)

Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study
by: Jing Yang, et al.
Published: (2025-01-01)

From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors
by: Mégane Jassin, et al.
Published: (2025-07-01)