Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
Despite treatment with immunosuppressive or clone-targeted chemotherapy, patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) frequently progress into end-stage kidney failure, and early recurrence of PGNMID after kidney transplantation is common. The standa...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Kidney Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059524001560 |
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| author | Zewei Chen Shangxi Fu Jun Wu Xiaoling Luo Zhiguo Mao Dechao Xu Xiang Gao |
| author_facet | Zewei Chen Shangxi Fu Jun Wu Xiaoling Luo Zhiguo Mao Dechao Xu Xiang Gao |
| author_sort | Zewei Chen |
| collection | DOAJ |
| description | Despite treatment with immunosuppressive or clone-targeted chemotherapy, patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) frequently progress into end-stage kidney failure, and early recurrence of PGNMID after kidney transplantation is common. The standard management of PGNMID has been unclear, currently based on data from small cohorts, which requires a need for additional therapeutic regimens in this disease. A human IgG monoclonal antibody that targets CD38 (daratumumab) was recently identified as a potential therapeutic option for treating PGNMID. To date, rare data on the application of daratumumab in patients with PGNMID after kidney transplantation have been reported. Herein, we first described a unique patient with recurrent PGNMID in kidney allograft who was treated with daratumumab after not responding to bortezomib-based regimens. Daratumumab was shown to successfully reduce proteinuria with stabilizing kidney function and was well-tolerated in this patient, which supports that daratumumab appears to be a viable option for treatment-resistant PGNMID. |
| format | Article |
| id | doaj-art-a70c2fd79509490db46c18ff9dad1e0f |
| institution | Kabale University |
| issn | 2590-0595 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj-art-a70c2fd79509490db46c18ff9dad1e0f2025-01-19T06:26:34ZengElsevierKidney Medicine2590-05952025-02-0172100945Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case ReportZewei Chen0Shangxi Fu1Jun Wu2Xiaoling Luo3Zhiguo Mao4Dechao Xu5Xiang Gao6Division of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China; Department of Nephrology, The First Navy Hospital of Southern Theater Command, Zhanjiang, Guangdong, ChinaDepartment of Urology, Kidney Transplantation Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaDivision of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China; Address for Correspondence: Xiang Gao, MD, PhD; Dechao Xu, MD, PhD; Zhiguo Mao, MD, PhD, Division of Nephrology, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China.Division of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China; Address for Correspondence: Xiang Gao, MD, PhD; Dechao Xu, MD, PhD; Zhiguo Mao, MD, PhD, Division of Nephrology, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China.Division of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China; Address for Correspondence: Xiang Gao, MD, PhD; Dechao Xu, MD, PhD; Zhiguo Mao, MD, PhD, Division of Nephrology, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China.Despite treatment with immunosuppressive or clone-targeted chemotherapy, patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) frequently progress into end-stage kidney failure, and early recurrence of PGNMID after kidney transplantation is common. The standard management of PGNMID has been unclear, currently based on data from small cohorts, which requires a need for additional therapeutic regimens in this disease. A human IgG monoclonal antibody that targets CD38 (daratumumab) was recently identified as a potential therapeutic option for treating PGNMID. To date, rare data on the application of daratumumab in patients with PGNMID after kidney transplantation have been reported. Herein, we first described a unique patient with recurrent PGNMID in kidney allograft who was treated with daratumumab after not responding to bortezomib-based regimens. Daratumumab was shown to successfully reduce proteinuria with stabilizing kidney function and was well-tolerated in this patient, which supports that daratumumab appears to be a viable option for treatment-resistant PGNMID.http://www.sciencedirect.com/science/article/pii/S2590059524001560Proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID)daratumumabkidney allograft |
| spellingShingle | Zewei Chen Shangxi Fu Jun Wu Xiaoling Luo Zhiguo Mao Dechao Xu Xiang Gao Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report Kidney Medicine Proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) daratumumab kidney allograft |
| title | Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report |
| title_full | Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report |
| title_fullStr | Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report |
| title_full_unstemmed | Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report |
| title_short | Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report |
| title_sort | daratumumab for bortezomib refractory proliferative glomerulonephritis with monoclonal immunoglobulin deposits in kidney allograft a case report |
| topic | Proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) daratumumab kidney allograft |
| url | http://www.sciencedirect.com/science/article/pii/S2590059524001560 |
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