TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study
Background: A substantial number of viable donor livers are discarded due to the donor's underlying malignancy. Concurrently, patients with certain liver malignancies – such as unresectable colorectal cancer liver metastases (CRC-LM), unresectable intrahepatic or perihilar cholangiocarcinoma (i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Contemporary Clinical Trials Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865425000390 |
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| author | Dominik Thomas Koch Malte Schirren Severin Jacobi Christian Lange Jens Werner Dionysios Koliogiannis Markus Guba |
| author_facet | Dominik Thomas Koch Malte Schirren Severin Jacobi Christian Lange Jens Werner Dionysios Koliogiannis Markus Guba |
| author_sort | Dominik Thomas Koch |
| collection | DOAJ |
| description | Background: A substantial number of viable donor livers are discarded due to the donor's underlying malignancy. Concurrently, patients with certain liver malignancies – such as unresectable colorectal cancer liver metastases (CRC-LM), unresectable intrahepatic or perihilar cholangiocarcinoma (iCCC/phCCC), or unresectable hepatocellular carcinoma (HCC) responding to immunotherapy – often face poor survival outcomes and are deemed ineligible for potentially curative liver transplantation. In this context, a rational risk-benefit analysis suggests that transplanting an organ with a theoretical risk of tumor transmission may be justifiable for these patients facing otherwise short-term fatal outcomes. Methods: The TRANSMIT study is a compassionate use exploratory study aimed at assessing the utility and safety of using donor organs from individuals with a current or past history of cancer for liver transplantation in patients with liver malignancies (CRC-LM, i/phCCC, HCC) who are not eligible for regular organ allocation. The study will evaluate the utilization rate of donor organs that would otherwise be discarded, overall survival, progression-free survival, and tumor transmission rates at one and three years, stratified by indication. Discussion: Donor organs from individuals with a current or past history of cancer may represent a valuable and safe resource for expanding the limited donor pool, particularly for patients who lack access to standard organ allocation. |
| format | Article |
| id | doaj-art-a70c1a4b28894bebafec700bf3d71756 |
| institution | DOAJ |
| issn | 2451-8654 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj-art-a70c1a4b28894bebafec700bf3d717562025-08-20T02:50:45ZengElsevierContemporary Clinical Trials Communications2451-86542025-04-014410146510.1016/j.conctc.2025.101465TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory studyDominik Thomas Koch0Malte Schirren1Severin Jacobi2Christian Lange3Jens Werner4Dionysios Koliogiannis5Markus Guba6Department of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, Germany; Corresponding author.Department of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, GermanyDepartment of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, GermanyDepartment of Internal Medicine II, LMU University Hospital, LMU, Munich, GermanyDepartment of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, GermanyDepartment of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, GermanyDepartment of General, Visceral and Transplant Surgery, LMU University Hospital, LMU, Munich, GermanyBackground: A substantial number of viable donor livers are discarded due to the donor's underlying malignancy. Concurrently, patients with certain liver malignancies – such as unresectable colorectal cancer liver metastases (CRC-LM), unresectable intrahepatic or perihilar cholangiocarcinoma (iCCC/phCCC), or unresectable hepatocellular carcinoma (HCC) responding to immunotherapy – often face poor survival outcomes and are deemed ineligible for potentially curative liver transplantation. In this context, a rational risk-benefit analysis suggests that transplanting an organ with a theoretical risk of tumor transmission may be justifiable for these patients facing otherwise short-term fatal outcomes. Methods: The TRANSMIT study is a compassionate use exploratory study aimed at assessing the utility and safety of using donor organs from individuals with a current or past history of cancer for liver transplantation in patients with liver malignancies (CRC-LM, i/phCCC, HCC) who are not eligible for regular organ allocation. The study will evaluate the utilization rate of donor organs that would otherwise be discarded, overall survival, progression-free survival, and tumor transmission rates at one and three years, stratified by indication. Discussion: Donor organs from individuals with a current or past history of cancer may represent a valuable and safe resource for expanding the limited donor pool, particularly for patients who lack access to standard organ allocation.http://www.sciencedirect.com/science/article/pii/S2451865425000390Liver transplantationTumor transmissionColorectal liver metastasesCholangiocarcinomaHepatocellular carcinoma |
| spellingShingle | Dominik Thomas Koch Malte Schirren Severin Jacobi Christian Lange Jens Werner Dionysios Koliogiannis Markus Guba TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study Contemporary Clinical Trials Communications Liver transplantation Tumor transmission Colorectal liver metastases Cholangiocarcinoma Hepatocellular carcinoma |
| title | TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study |
| title_full | TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study |
| title_fullStr | TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study |
| title_full_unstemmed | TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study |
| title_short | TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation - A compassionate use exploratory study |
| title_sort | transmit utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation a compassionate use exploratory study |
| topic | Liver transplantation Tumor transmission Colorectal liver metastases Cholangiocarcinoma Hepatocellular carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2451865425000390 |
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