Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil
Background/Objectives: Lip cancer represents one of the most prevalent malignant neoplasms in the oral cavity worldwide. This study investigated the prevalence, epidemiological profile, and survival rates of lip squamous cell carcinoma cases at the Liga Norte Riograndense Contra o Câncer (LNRCC) thr...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Onco |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-7523/5/1/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342401791918080 |
|---|---|
| author | Guilherme Carlos Beiruth Freire Luiz Eduardo Rodrigues Juliasse Salomão Israel Monteiro Lourenço Queiroz Ruthinéia Diógenes Alves Uchôa Lins Carlos Fernando Mourão Bruno César de Vasconcelos Gurgel |
| author_facet | Guilherme Carlos Beiruth Freire Luiz Eduardo Rodrigues Juliasse Salomão Israel Monteiro Lourenço Queiroz Ruthinéia Diógenes Alves Uchôa Lins Carlos Fernando Mourão Bruno César de Vasconcelos Gurgel |
| author_sort | Guilherme Carlos Beiruth Freire |
| collection | DOAJ |
| description | Background/Objectives: Lip cancer represents one of the most prevalent malignant neoplasms in the oral cavity worldwide. This study investigated the prevalence, epidemiological profile, and survival rates of lip squamous cell carcinoma cases at the Liga Norte Riograndense Contra o Câncer (LNRCC) through a 15-year retrospective analysis. Methods: Data collection included sociodemographic characteristics, risk factors, tumor features, staging, and treatment modalities from 348 patient records. Statistical analysis was performed using Stata 12.0 and SPSS 22.0. Results: Results showed a predominance of male patients (70.4%), with a mean age of 65.51 years, mostly brown-skinned, illiterate individuals working in rural areas and residing in the state’s eastern region. Moderately differentiated squamous cell carcinoma (82.8%) affecting the lower lip (89.1%) was most frequent, with a tendency toward advanced staging. The overall survival rate was 88.90%, with lower rates observed among white, illiterate, and substance-using patients, as well as those with advanced-stage disease and chemotherapy treatment. Conclusions: Notably, race emerged as the most significant survival predictor, with white individuals showing consistently lower survival rates regardless of disease characteristics or treatment approach. |
| format | Article |
| id | doaj-art-a70b0db3ecad409c8543a8bbfefec5f8 |
| institution | Kabale University |
| issn | 2673-7523 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Onco |
| spelling | doaj-art-a70b0db3ecad409c8543a8bbfefec5f82025-08-20T03:43:25ZengMDPI AGOnco2673-75232025-01-0151410.3390/onco5010004Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern BrazilGuilherme Carlos Beiruth Freire0Luiz Eduardo Rodrigues Juliasse1Salomão Israel Monteiro Lourenço Queiroz2Ruthinéia Diógenes Alves Uchôa Lins3Carlos Fernando Mourão4Bruno César de Vasconcelos Gurgel5Department of Dentistry, Federal University of Rio Grande do Norte, Natal 59056-000, RN, BrazilDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal 59056-000, RN, BrazilDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal 59056-000, RN, BrazilDepartment of Dentistry, Federal University of Rio Grande do Norte, Natal 59056-000, RN, BrazilDepartment of Basic and Clinical Translational Sciences, Tufts University School of Dental Medicine, Boston, MA 02111, USADepartment of Dentistry, Federal University of Rio Grande do Norte, Natal 59056-000, RN, BrazilBackground/Objectives: Lip cancer represents one of the most prevalent malignant neoplasms in the oral cavity worldwide. This study investigated the prevalence, epidemiological profile, and survival rates of lip squamous cell carcinoma cases at the Liga Norte Riograndense Contra o Câncer (LNRCC) through a 15-year retrospective analysis. Methods: Data collection included sociodemographic characteristics, risk factors, tumor features, staging, and treatment modalities from 348 patient records. Statistical analysis was performed using Stata 12.0 and SPSS 22.0. Results: Results showed a predominance of male patients (70.4%), with a mean age of 65.51 years, mostly brown-skinned, illiterate individuals working in rural areas and residing in the state’s eastern region. Moderately differentiated squamous cell carcinoma (82.8%) affecting the lower lip (89.1%) was most frequent, with a tendency toward advanced staging. The overall survival rate was 88.90%, with lower rates observed among white, illiterate, and substance-using patients, as well as those with advanced-stage disease and chemotherapy treatment. Conclusions: Notably, race emerged as the most significant survival predictor, with white individuals showing consistently lower survival rates regardless of disease characteristics or treatment approach.https://www.mdpi.com/2673-7523/5/1/4epidermoid lip carcinomaprevalenceepidemiologysurvival |
| spellingShingle | Guilherme Carlos Beiruth Freire Luiz Eduardo Rodrigues Juliasse Salomão Israel Monteiro Lourenço Queiroz Ruthinéia Diógenes Alves Uchôa Lins Carlos Fernando Mourão Bruno César de Vasconcelos Gurgel Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil Onco epidermoid lip carcinoma prevalence epidemiology survival |
| title | Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil |
| title_full | Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil |
| title_fullStr | Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil |
| title_full_unstemmed | Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil |
| title_short | Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil |
| title_sort | survival patterns and prognostic factors in lip cancer patients a 15 year single center experience from northeastern brazil |
| topic | epidermoid lip carcinoma prevalence epidemiology survival |
| url | https://www.mdpi.com/2673-7523/5/1/4 |
| work_keys_str_mv | AT guilhermecarlosbeiruthfreire survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil AT luizeduardorodriguesjuliasse survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil AT salomaoisraelmonteirolourencoqueiroz survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil AT ruthineiadiogenesalvesuchoalins survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil AT carlosfernandomourao survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil AT brunocesardevasconcelosgurgel survivalpatternsandprognosticfactorsinlipcancerpatientsa15yearsinglecenterexperiencefromnortheasternbrazil |