Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil

Survival Patterns and Prognostic Factors in Lip Cancer Patients: A 15-Year Single-Center Experience from Northeastern Brazil

Background/Objectives: Lip cancer represents one of the most prevalent malignant neoplasms in the oral cavity worldwide. This study investigated the prevalence, epidemiological profile, and survival rates of lip squamous cell carcinoma cases at the Liga Norte Riograndense Contra o Câncer (LNRCC) thr...

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Main Authors: Guilherme Carlos Beiruth Freire, Luiz Eduardo Rodrigues Juliasse, Salomão Israel Monteiro Lourenço Queiroz, Ruthinéia Diógenes Alves Uchôa Lins, Carlos Fernando Mourão, Bruno César de Vasconcelos Gurgel
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Onco
Subjects:
epidermoid lip carcinoma
prevalence
epidemiology
survival
Online Access:https://www.mdpi.com/2673-7523/5/1/4
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Summary:Background/Objectives: Lip cancer represents one of the most prevalent malignant neoplasms in the oral cavity worldwide. This study investigated the prevalence, epidemiological profile, and survival rates of lip squamous cell carcinoma cases at the Liga Norte Riograndense Contra o Câncer (LNRCC) through a 15-year retrospective analysis. Methods: Data collection included sociodemographic characteristics, risk factors, tumor features, staging, and treatment modalities from 348 patient records. Statistical analysis was performed using Stata 12.0 and SPSS 22.0. Results: Results showed a predominance of male patients (70.4%), with a mean age of 65.51 years, mostly brown-skinned, illiterate individuals working in rural areas and residing in the state’s eastern region. Moderately differentiated squamous cell carcinoma (82.8%) affecting the lower lip (89.1%) was most frequent, with a tendency toward advanced staging. The overall survival rate was 88.90%, with lower rates observed among white, illiterate, and substance-using patients, as well as those with advanced-stage disease and chemotherapy treatment. Conclusions: Notably, race emerged as the most significant survival predictor, with white individuals showing consistently lower survival rates regardless of disease characteristics or treatment approach.
ISSN:2673-7523

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