Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma

Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma

Objective Glaucoma is a common neurodegenerative disease resulting in irreversible blindness. This study investigates whether fucoxanthin can safeguard retinal ganglion cells (RGCs) by modulating Parkin-mediated mitophagy in experimental glaucoma.Methods An experimental glaucomatous model was induc...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lifang Zhang, Dandan Wang, Qinkang Lu, Haixia Ma, Xinxin Hu, Juntao Zhang, Wei Lian
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-08-01
Series:	BMJ Open Ophthalmology
Online Access:	https://bmjophth.bmj.com/content/10/1/e002126.full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

SHMT2 overexpression improves glaucoma by enhancing mitophagy in retinal ganglion cells through promoting the phospho of PINK1
by: Liying Cui, et al.
Published: (2025-07-01)

Retroviral foamy virus gag induces parkin-dependent mitophagy
by: Shanshan Wang, et al.
Published: (2025-05-01)

PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning
by: Xuetao Ji, et al.
Published: (2025-07-01)

Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy
by: Ruonan Yang, et al.
Published: (2025-10-01)

USP14 inhibition enhances Parkin-independent mitophagy in iNeurons
by: Greta Bernardo, et al.
Published: (2024-12-01)

Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy
by: Robert Weil, et al.
Published: (2024-12-01)

DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy
by: Jinjin Ma, et al.
Published: (2025-07-01)

Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy
by: Bin Jiang, et al.
Published: (2025-05-01)

Correction: DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy
by: Jinjin Ma, et al.
Published: (2025-08-01)

Glaucomatous retinal ganglion cells: death and protection
by: Na Cui, et al.
Published: (2025-01-01)

Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma
by: Nisha Rajakrishna, et al.
Published: (2025-04-01)

The PINK1-Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells.
by: Aaron V Bradshaw, et al.
Published: (2021-01-01)

PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection
by: Yuan Zhao, et al.
Published: (2024-12-01)

JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy
by: Ya Xie, et al.
Published: (2025-03-01)

Protective Effect of Lycopene on Ifosfamide-Induced Mitophagy through Pink, Parkin, and LC3-I/II Pathway in Testicular Tissue
by: Ali Thoulfikar A. Imeer, et al.
Published: (2025-07-01)

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy.
by: Hongmei Qian, et al.
Published: (2024-01-01)

VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1/Parkin-mediated mitophagy pathway
by: Yang Zhang, et al.
Published: (2025-07-01)

Forskolin attenuates doxorubicin-induced cardiotoxicity by activating SIRT1/FOXO1/PINK1/Parkin-mediated mitophagy
by: Yomna S. Momen, et al.
Published: (2025-06-01)

Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice
by: Zhenyu Zou, et al.
Published: (2025-04-01)

Retinal Vessel Diameter Reductions Are Associated with Retinal Ganglion Cell Dysfunction, Thinning of the Ganglion Cell and Inner Plexiform Layers, and Decreased Visual Field Global Indices in Glaucoma Suspects
by: Andrew Tirsi, et al.
Published: (2025-07-01)

Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway
by: Chao Chen, et al.
Published: (2025-07-01)

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse
by: Yan‐Wei Song, et al.
Published: (2025-05-01)

The influence of venous blood flow on the retinal ganglion cell complex in patients with primary open angle glaucoma
by: N. I. Kurysheva, et al.
Published: (2014-07-01)

Retraction: RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy.
by: PLOS One Editors
Published: (2025-01-01)

Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy
by: Sara E. Ratican, et al.
Published: (2018-01-01)

PANoptosis of Retinal Ganglion Cells
by: Yixiang Jiang, et al.
Published: (2025-07-01)

Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice
by: Tianchan Peng, et al.
Published: (2025-02-01)

Tubeimoside I induces mitophagy by activating the PINK1/Parkin/Mfn2 signaling pathway in acute myeloid leukemia cells
by: Jing Xu, et al.
Published: (2025-05-01)

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population
by: Almila Sarıgül Sezenöz, et al.
Published: (2020-01-01)

Percentage macular ganglion cell complex and peripapillary retinal nerve fiber layer loss in different stages of glaucoma
by: Shah Zalak, et al.
Published: (2025-03-01)

Novel Structure–Function Models for Estimating Retinal Ganglion Cell Count Using Pattern Electroretinography in Glaucoma Suspects
by: Andrew Tirsi, et al.
Published: (2025-07-01)

Steady-State PERG Adaptation Reveals Temporal Abnormalities of Retinal Ganglion Cells in Treated Ocular Hypertension and Glaucoma
by: Tommaso Salgarello, et al.
Published: (2025-07-01)

The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness Changes in Glaucoma
by: Jin A Choi, et al.
Published: (2017-01-01)

Hydrogen sulfide attenuates PM2.5-induced COPD by inhibiting cellular senescence via the Klotho/Parkin-mediated mitophagy signaling pathway
by: Ying Wang, et al.
Published: (2025-03-01)

Corrigendum: HIF-1α alleviates high-glucose-induced renal tubular cell injury by promoting Parkin/PINK1-mediated mitophagy
by: Lu Yu, et al.
Published: (2025-03-01)

Encoding surprise by retinal ganglion cells.
by: Danica Despotović, et al.
Published: (2024-04-01)

Macular vascular density changes in different stages of chronic primary angle-closure glaucoma
by: Juntao Zhang, et al.
Published: (2025-07-01)

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress
by: Haicheng Ye, et al.
Published: (2025-04-01)

Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway
by: Haijing Dou, et al.
Published: (2025-08-01)

Non-pathogenic Trojan horse Nissle1917 triggers mitophagy through PINK1/Parkin pathway to discourage colon cancer
by: Yang Wang, et al.
Published: (2024-12-01)