Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma

Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma

Abstract Pediatric obesity-related asthma is characterized by non-atopic T helper 1 (Th1) inflammation and steroid resistance. CDC42 upregulation in CD4 + T cells underlies Th1 inflammation but the CD4 + T cell subtype(s) with CDC42 upregulation and their contribution to steroid resistance are not k...

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Bibliographic Details
Main Authors: David A. Thompson, Yvonne B. Wabara, Sarai Duran, Anna Reichenbach, Laura Chen, Kayla Collado, Changsuek Yon, John M. Greally DMed, Deepa Rastogi
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Obesity
Asthma
CD4 + T cells
Children
Online Access:https://doi.org/10.1038/s41598-025-88423-4
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