TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies
Cancer is a therapeutically challenging and genomically complicated disease. Pioneering studies have uncovered multifaceted aspects of cancer, ranging from intra- and inter-tumor heterogeneity, drug resistance, and genetic/epigenetic mutations. Loss of apoptosis is another critical aspect that makes...
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2024-12-01
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| author | Ammad Ahmad Farooqi Assiya Turgambayeva Gulnara Kamalbekova Roza Suleimenova Natalya Latypova Sholpan Ospanova Dinara Ospanova Zhanat Abdikadyr Sabit Zhussupov |
| author_facet | Ammad Ahmad Farooqi Assiya Turgambayeva Gulnara Kamalbekova Roza Suleimenova Natalya Latypova Sholpan Ospanova Dinara Ospanova Zhanat Abdikadyr Sabit Zhussupov |
| author_sort | Ammad Ahmad Farooqi |
| collection | DOAJ |
| description | Cancer is a therapeutically challenging and genomically complicated disease. Pioneering studies have uncovered multifaceted aspects of cancer, ranging from intra- and inter-tumor heterogeneity, drug resistance, and genetic/epigenetic mutations. Loss of apoptosis is another critical aspect that makes cancer cells resistant to death. A substantial fraction of mechanistic information gleaned from cutting-edge studies has enabled researchers to develop near-to-complete resolution of the apoptotic pathway. Within the exciting frontiers of apoptosis, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) has garnered phenomenal appreciation by interdisciplinary researchers principally because of its unique capability to target cancer cells. TRAIL-based monotherapies and combinatorial therapies have reached phase II and phase III clinical trials. Rapidly upgrading the list of clinical trials substantiates the clinically valuable role of TRAIL-based therapeutics in cancer therapy. However, there is a growing concern about the poor bioavailability and rapid clearance of TRAIL-based therapeutics. Excitingly, the charismatic field of nanotechnology offers solutions for different problems, and we have witnessed remarkable breakthroughs in the efficacy of TRAIL-based therapeutics using nanotechnological approaches. In this review, we have attempted to provide a summary about different nanotechnologically assisted delivery methods for TRAIL-based therapeutics in cell culture studies and animal model studies for the inhibition/prevention of cancer. |
| format | Article |
| id | doaj-art-a6f83cc49f5e45ef8a664fa55659e727 |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-a6f83cc49f5e45ef8a664fa55659e7272025-08-20T02:00:43ZengMDPI AGMedicina1010-660X1648-91442024-12-016012197710.3390/medicina60121977TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model StudiesAmmad Ahmad Farooqi0Assiya Turgambayeva1Gulnara Kamalbekova2Roza Suleimenova3Natalya Latypova4Sholpan Ospanova5Dinara Ospanova6Zhanat Abdikadyr7Sabit Zhussupov8Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 44090, PakistanDepartment of Public Health and Management, Astana Medical University, Astana 010000, KazakhstanDepartment of Family Medicine, Astana Medical University, Astana 010000, KazakhstanDepartment of Public Health and Hygiene, Astana Medical University, Astana 010000, KazakhstanDepartment of Family Medicine, Astana Medical University, Astana 010000, KazakhstanDepartment of Public Health and Management, Astana Medical University, Astana 010000, KazakhstanFaculty of Medicine and Healthcare, Al-Farabi Kazakh National University, 71 Al-Farabi Ave, Almaty 050040, KazakhstanDepartment of Biostatistics, Bioinformatics and Information Technologies, Astana Medical University, Astana 010000, KazakhstanDepartment of Surgery, Semey Medical University, Semey 071400, KazakhstanCancer is a therapeutically challenging and genomically complicated disease. Pioneering studies have uncovered multifaceted aspects of cancer, ranging from intra- and inter-tumor heterogeneity, drug resistance, and genetic/epigenetic mutations. Loss of apoptosis is another critical aspect that makes cancer cells resistant to death. A substantial fraction of mechanistic information gleaned from cutting-edge studies has enabled researchers to develop near-to-complete resolution of the apoptotic pathway. Within the exciting frontiers of apoptosis, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) has garnered phenomenal appreciation by interdisciplinary researchers principally because of its unique capability to target cancer cells. TRAIL-based monotherapies and combinatorial therapies have reached phase II and phase III clinical trials. Rapidly upgrading the list of clinical trials substantiates the clinically valuable role of TRAIL-based therapeutics in cancer therapy. However, there is a growing concern about the poor bioavailability and rapid clearance of TRAIL-based therapeutics. Excitingly, the charismatic field of nanotechnology offers solutions for different problems, and we have witnessed remarkable breakthroughs in the efficacy of TRAIL-based therapeutics using nanotechnological approaches. In this review, we have attempted to provide a summary about different nanotechnologically assisted delivery methods for TRAIL-based therapeutics in cell culture studies and animal model studies for the inhibition/prevention of cancer.https://www.mdpi.com/1648-9144/60/12/1977TRAILapoptosiscell signalingmetastasisxenografted micenanotechnology |
| spellingShingle | Ammad Ahmad Farooqi Assiya Turgambayeva Gulnara Kamalbekova Roza Suleimenova Natalya Latypova Sholpan Ospanova Dinara Ospanova Zhanat Abdikadyr Sabit Zhussupov TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies Medicina TRAIL apoptosis cell signaling metastasis xenografted mice nanotechnology |
| title | TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies |
| title_full | TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies |
| title_fullStr | TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies |
| title_full_unstemmed | TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies |
| title_short | TRAIL as a Warrior in Nano-Sized Trojan Horse: Anticancer and Anti-Metastatic Effects of Nano-Formulations of TRAIL in Cell Culture and Animal Model Studies |
| title_sort | trail as a warrior in nano sized trojan horse anticancer and anti metastatic effects of nano formulations of trail in cell culture and animal model studies |
| topic | TRAIL apoptosis cell signaling metastasis xenografted mice nanotechnology |
| url | https://www.mdpi.com/1648-9144/60/12/1977 |
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