Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)

Background: Chronic systemic disease known as diabetes mellitus (DM) is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary anti...

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Main Authors: Budiastuti Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, Agung Prasetyo
Format: Article
Language:English
Published: Tripoli University 2025-02-01
Series:Open Veterinary Journal
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Online Access:http://www.ejmanager.com/fulltextpdf.php?mno=234043
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author Budiastuti Budiastuti
Naomi Lan Noviana Thesia
Hani Plumeriastuti
Mustofa Helmi Effendi
Emmanuel Nnabuike Ugbo
Aswin Rafif Khairullah
Ikechukwu Benjamin Moses
Katty Hendriana Priscilia Riwu
Riza Zainuddin Ahmad
Sheila Marty Yanestria
Wasito Wasito
Bima Putra Pratama
Mo Awwanah
Agung Prasetyo
author_facet Budiastuti Budiastuti
Naomi Lan Noviana Thesia
Hani Plumeriastuti
Mustofa Helmi Effendi
Emmanuel Nnabuike Ugbo
Aswin Rafif Khairullah
Ikechukwu Benjamin Moses
Katty Hendriana Priscilia Riwu
Riza Zainuddin Ahmad
Sheila Marty Yanestria
Wasito Wasito
Bima Putra Pratama
Mo Awwanah
Agung Prasetyo
author_sort Budiastuti Budiastuti
collection DOAJ
description Background: Chronic systemic disease known as diabetes mellitus (DM) is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary antioxidant chemicals found in Cinnamomum burmanii bark extract are polyphenols, which include tannins and flavonoids. Aim: The antidiabetic activity of cinnamon essential oil (Cinnamomum burmannii) against streptozotocin (STZ) was examined in this study. Methods: STZ (45 mg/kgBW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with streptozotocin and provided with 100 mg/kgBW; treatment 2 (P2) was administered with streptozotocin and provided with 200 mg/kgBW; and treatment 3 (P3) was administered with streptozotocin and provided with 400 mg/kgBW. The negative control group (K-) was not treated with streptozotocin and was treated with 1% Tween 80. For 14 days, the medication was administered daily. Results: The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kgBW) produced negligible effects. Conclusion: It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage. [Open Vet J 2025; 15(2.000): 923-930]
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spelling doaj-art-a6f582e4f287463ca2587e196a74e40b2025-08-20T02:28:02ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502025-02-0115292393010.5455/OVJ.2025.v15.i2.41234043Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)Budiastuti Budiastuti0Naomi Lan Noviana Thesia1Hani Plumeriastuti2Mustofa Helmi Effendi3Emmanuel Nnabuike Ugbo4Aswin Rafif Khairullah5Ikechukwu Benjamin Moses6Katty Hendriana Priscilia Riwu7Riza Zainuddin Ahmad8Sheila Marty Yanestria9Wasito Wasito10Bima Putra Pratama11Mo Awwanah12Agung Prasetyo13Study Program of Pharmacy Science, Faculty of Health Science, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia Master Program of Veterinary Science and Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia Division of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia Division of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Mataram, Indonesia Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, Indonesia Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia Research Center for Agroindustry, National Research and Innovation Agency (BRIN), Bogor, Indonesia Research Center for Applied Botany, National Research and Innovation Agency (BRIN), Bogor, Indonesia Research Center for Estate Crops, National Research and Innovation Agency (BRIN), Bogor, IndonesiaBackground: Chronic systemic disease known as diabetes mellitus (DM) is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary antioxidant chemicals found in Cinnamomum burmanii bark extract are polyphenols, which include tannins and flavonoids. Aim: The antidiabetic activity of cinnamon essential oil (Cinnamomum burmannii) against streptozotocin (STZ) was examined in this study. Methods: STZ (45 mg/kgBW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with streptozotocin and provided with 100 mg/kgBW; treatment 2 (P2) was administered with streptozotocin and provided with 200 mg/kgBW; and treatment 3 (P3) was administered with streptozotocin and provided with 400 mg/kgBW. The negative control group (K-) was not treated with streptozotocin and was treated with 1% Tween 80. For 14 days, the medication was administered daily. Results: The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kgBW) produced negligible effects. Conclusion: It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage. [Open Vet J 2025; 15(2.000): 923-930]http://www.ejmanager.com/fulltextpdf.php?mno=234043cinnamomum burmanniiessential oilkidneystreptozotocinantidiabetic
spellingShingle Budiastuti Budiastuti
Naomi Lan Noviana Thesia
Hani Plumeriastuti
Mustofa Helmi Effendi
Emmanuel Nnabuike Ugbo
Aswin Rafif Khairullah
Ikechukwu Benjamin Moses
Katty Hendriana Priscilia Riwu
Riza Zainuddin Ahmad
Sheila Marty Yanestria
Wasito Wasito
Bima Putra Pratama
Mo Awwanah
Agung Prasetyo
Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
Open Veterinary Journal
cinnamomum burmannii
essential oil
kidney
streptozotocin
antidiabetic
title Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
title_full Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
title_fullStr Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
title_full_unstemmed Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
title_short Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)
title_sort effect of cinnamon oil cinnamomum burmannii on the histological kidney of male diabetic rats rattus norvegicus
topic cinnamomum burmannii
essential oil
kidney
streptozotocin
antidiabetic
url http://www.ejmanager.com/fulltextpdf.php?mno=234043
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