The characteristics of Korean elderly multiple myeloma patients aged 80 years or over
Background/Aims Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed. Methods This retrospective multicenter study...
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The Korean Association of Internal Medicine
2025-01-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://kjim.org/upload/kjim-2024-041.pdf |
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| author | Sang Hwan Lee Hee-Jeong Cho Joon Ho Moon Ji Yoon Jung Min Kyoung Kim Mi Hwa Heo Young Rok Do Yunhwi Hwang Sung Hwa Bae |
| author_facet | Sang Hwan Lee Hee-Jeong Cho Joon Ho Moon Ji Yoon Jung Min Kyoung Kim Mi Hwa Heo Young Rok Do Yunhwi Hwang Sung Hwa Bae |
| author_sort | Sang Hwan Lee |
| collection | DOAJ |
| description | Background/Aims Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed. Methods This retrospective multicenter study was conducted to investigate the clinical characteristics, treatment patterns, and survival outcomes of patients aged 80 years or over who were newly diagnosed with MM at five academic hospitals in Daegu, Korea, between 2010 and 2019. Results A total of 127 patients with a median age of 83 years (range, 80–93 yr) were enrolled: 52 (40.9%) with Eastern Cooperative Oncology Group Performance Status (ECOG PS) > 2, 84 (66.1%) with International Staging System (ISS) stage III disease, and 93 (73.2%) with a Charlson comorbidity index (CCI) > 4. Chemotherapy was administered to 86 patients (67.7%). The median overall survival was 9.3 months. Overall survival was significantly associated with ECOG PS > 2 (HR 2.26, 95% CI 1.43–3.59), ISS stage III (HR 1.99, 95% CI 1.18–3.34), and chemotherapy (HR 0.34, 95% CI 0.21–0.55). There was no statistically significant difference in event-free survival according to the type of anti-myeloma chemotherapy administered. The early mortality (EM) rate was 28.3%. Conclusions Even in patients with MM aged 80 years or over, chemotherapy can result in better survival outcomes than supportive care. Patients aged ≥ 80 years should not be excluded from chemotherapy based on age alone. However, reducing EM in elderly patients with newly diagnosed MM remains challenging. |
| format | Article |
| id | doaj-art-a6f303ad0c694ae1a66c2e6b6dbd149d |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-a6f303ad0c694ae1a66c2e6b6dbd149d2025-08-20T03:04:26ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-01-0140111512310.3904/kjim.2024.041170987The characteristics of Korean elderly multiple myeloma patients aged 80 years or overSang Hwan Lee0Hee-Jeong Cho1Joon Ho Moon2Ji Yoon Jung3Min Kyoung Kim4Mi Hwa Heo5Young Rok Do6Yunhwi Hwang7Sung Hwa Bae8 Department of Hematology/Oncology, Daegu Fatima Hospital, Daegu, Korea Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea Department of Hematology/Oncology, Yeungnam University Medical Center, Daegu, Korea Department of Hematology/Oncology, Yeungnam University Medical Center, Daegu, Korea Department of Hematology/Oncology, Keimyung University Dongsan Medical Center, Daegu, Korea Department of Hematology/Oncology, Keimyung University Dongsan Medical Center, Daegu, Korea Department of Hematology/Oncology, Daegu Catholic University Medical Center, Daegu, Korea Department of Hematology/Oncology, Daegu Catholic University Medical Center, Daegu, KoreaBackground/Aims Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed. Methods This retrospective multicenter study was conducted to investigate the clinical characteristics, treatment patterns, and survival outcomes of patients aged 80 years or over who were newly diagnosed with MM at five academic hospitals in Daegu, Korea, between 2010 and 2019. Results A total of 127 patients with a median age of 83 years (range, 80–93 yr) were enrolled: 52 (40.9%) with Eastern Cooperative Oncology Group Performance Status (ECOG PS) > 2, 84 (66.1%) with International Staging System (ISS) stage III disease, and 93 (73.2%) with a Charlson comorbidity index (CCI) > 4. Chemotherapy was administered to 86 patients (67.7%). The median overall survival was 9.3 months. Overall survival was significantly associated with ECOG PS > 2 (HR 2.26, 95% CI 1.43–3.59), ISS stage III (HR 1.99, 95% CI 1.18–3.34), and chemotherapy (HR 0.34, 95% CI 0.21–0.55). There was no statistically significant difference in event-free survival according to the type of anti-myeloma chemotherapy administered. The early mortality (EM) rate was 28.3%. Conclusions Even in patients with MM aged 80 years or over, chemotherapy can result in better survival outcomes than supportive care. Patients aged ≥ 80 years should not be excluded from chemotherapy based on age alone. However, reducing EM in elderly patients with newly diagnosed MM remains challenging.http://kjim.org/upload/kjim-2024-041.pdfmultiple myelomaelderlychemotherapy |
| spellingShingle | Sang Hwan Lee Hee-Jeong Cho Joon Ho Moon Ji Yoon Jung Min Kyoung Kim Mi Hwa Heo Young Rok Do Yunhwi Hwang Sung Hwa Bae The characteristics of Korean elderly multiple myeloma patients aged 80 years or over The Korean Journal of Internal Medicine multiple myeloma elderly chemotherapy |
| title | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over |
| title_full | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over |
| title_fullStr | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over |
| title_full_unstemmed | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over |
| title_short | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over |
| title_sort | characteristics of korean elderly multiple myeloma patients aged 80 years or over |
| topic | multiple myeloma elderly chemotherapy |
| url | http://kjim.org/upload/kjim-2024-041.pdf |
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