What can a tandem of a pathophysiologist and a clinician bring to clinical practice?
Kidney diseases, starting from acute kidney injury, acute kidney disease, or having an uncertain onset, often progress to chronic kidney disease (CKD). The pathomorphosis of this progression typically involves predominant damage to the glomerulus, affecting either the glomerular filter or the tubul...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2024-06-01
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| Series: | Počki |
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| Online Access: | https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/451 |
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| author | A.I. Gozhenko D.D. Ivanov |
| author_facet | A.I. Gozhenko D.D. Ivanov |
| author_sort | A.I. Gozhenko |
| collection | DOAJ |
| description | Kidney diseases, starting from acute kidney injury, acute kidney disease, or having an uncertain onset, often progress to chronic kidney disease (CKD). The pathomorphosis of this progression typically involves predominant damage to the glomerulus, affecting either the glomerular filter or the tubules, primarily in the proximal part. International guidelines identify two key indicators for determining the prognosis and progression of CKD: albuminuria and glomerular filtration rate. Additional criteria, such as blood pressure, pathomorphological changes, or multifactorial calculators, are usually proposed for specific nosological forms. However, accurately predicting CKD progression remains a challenging issue. We propose using renal functional reserve to estimate the number of functioning nephrons. Together with blood pressure, degrees of albuminuria, and glomerular filtration rate, this approach provides a more accurate assessment of the future course of CKD. |
| format | Article |
| id | doaj-art-a6f2cc05389e41ebbfa7269398defd8e |
| institution | OA Journals |
| issn | 2307-1257 2307-1265 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Počki |
| spelling | doaj-art-a6f2cc05389e41ebbfa7269398defd8e2025-08-20T02:13:40ZengZaslavsky O.Yu.Počki2307-12572307-12652024-06-011329610010.22141/2307-1257.13.2.2024.451451What can a tandem of a pathophysiologist and a clinician bring to clinical practice?A.I. Gozhenko0https://orcid.org/0000-0001-7413-4173D.D. Ivanov1https://orcid.org/0000-0003-2609-0051State Enterprise “Ukrainian Research Institute of Transport Medicine” of the Ministry of Health of Ukraine, Odesa, UkraineBogomolets National Medical University, Kyiv, UkraineKidney diseases, starting from acute kidney injury, acute kidney disease, or having an uncertain onset, often progress to chronic kidney disease (CKD). The pathomorphosis of this progression typically involves predominant damage to the glomerulus, affecting either the glomerular filter or the tubules, primarily in the proximal part. International guidelines identify two key indicators for determining the prognosis and progression of CKD: albuminuria and glomerular filtration rate. Additional criteria, such as blood pressure, pathomorphological changes, or multifactorial calculators, are usually proposed for specific nosological forms. However, accurately predicting CKD progression remains a challenging issue. We propose using renal functional reserve to estimate the number of functioning nephrons. Together with blood pressure, degrees of albuminuria, and glomerular filtration rate, this approach provides a more accurate assessment of the future course of CKD.https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/451renal functional reservechronic kidney diseaseacute kidney injuryacute kidney diseasepathogenesis of kidney diseases |
| spellingShingle | A.I. Gozhenko D.D. Ivanov What can a tandem of a pathophysiologist and a clinician bring to clinical practice? Počki renal functional reserve chronic kidney disease acute kidney injury acute kidney disease pathogenesis of kidney diseases |
| title | What can a tandem of a pathophysiologist and a clinician bring to clinical practice? |
| title_full | What can a tandem of a pathophysiologist and a clinician bring to clinical practice? |
| title_fullStr | What can a tandem of a pathophysiologist and a clinician bring to clinical practice? |
| title_full_unstemmed | What can a tandem of a pathophysiologist and a clinician bring to clinical practice? |
| title_short | What can a tandem of a pathophysiologist and a clinician bring to clinical practice? |
| title_sort | what can a tandem of a pathophysiologist and a clinician bring to clinical practice |
| topic | renal functional reserve chronic kidney disease acute kidney injury acute kidney disease pathogenesis of kidney diseases |
| url | https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/451 |
| work_keys_str_mv | AT aigozhenko whatcanatandemofapathophysiologistandaclinicianbringtoclinicalpractice AT ddivanov whatcanatandemofapathophysiologistandaclinicianbringtoclinicalpractice |