Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases
Outbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential. Compared to traditional injectable vaccines, mucosal vaccines have the potential to o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1573037/full |
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| author | Zhihan Zhang Yumeng Yang Liwen Huang Lei Yuan Sijian Huang Zihang Zeng Yuan Cao Yuan Cao Xianghong Wei Xiaomei Wang Mingsong Shi Maohua Zhong |
| author_facet | Zhihan Zhang Yumeng Yang Liwen Huang Lei Yuan Sijian Huang Zihang Zeng Yuan Cao Yuan Cao Xianghong Wei Xiaomei Wang Mingsong Shi Maohua Zhong |
| author_sort | Zhihan Zhang |
| collection | DOAJ |
| description | Outbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential. Compared to traditional injectable vaccines, mucosal vaccines have the potential to offer more effective immune protection at mucosal sites. Mucosal immunization strategies include sublingual, oral, intranasal, genital, and rectal routes, in which intranasal immunization being the most efficient and applicable method for mucosal vaccine delivery. Nevertheless, low antigen availability and weak immunogenicity making it challenging to elicit a potent immune response when administered intranasally, necessitating the incorporation of immune delivery systems. However, there is a notable absence of reviews that summarize the intranasal vaccine delivery system against infectious disease. Therefore, this review summarizes the recent advances in intranasal delivery systems, classified by physical and chemical properties, and proposes potential improvement strategies for clinical translation. This review elucidates the potential and current status of intranasal delivery systems, while also serving as a reference point for the future development of intranasal vaccines. |
| format | Article |
| id | doaj-art-a6ec86261d284eaba3cd76748259f6d8 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a6ec86261d284eaba3cd76748259f6d82025-08-20T02:16:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15730371573037Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseasesZhihan Zhang0Yumeng Yang1Liwen Huang2Lei Yuan3Sijian Huang4Zihang Zeng5Yuan Cao6Yuan Cao7Xianghong Wei8Xiaomei Wang9Mingsong Shi10Maohua Zhong11Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaAnalytical & Testing Center, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaNHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, ChinaInstitute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaOutbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential. Compared to traditional injectable vaccines, mucosal vaccines have the potential to offer more effective immune protection at mucosal sites. Mucosal immunization strategies include sublingual, oral, intranasal, genital, and rectal routes, in which intranasal immunization being the most efficient and applicable method for mucosal vaccine delivery. Nevertheless, low antigen availability and weak immunogenicity making it challenging to elicit a potent immune response when administered intranasally, necessitating the incorporation of immune delivery systems. However, there is a notable absence of reviews that summarize the intranasal vaccine delivery system against infectious disease. Therefore, this review summarizes the recent advances in intranasal delivery systems, classified by physical and chemical properties, and proposes potential improvement strategies for clinical translation. This review elucidates the potential and current status of intranasal delivery systems, while also serving as a reference point for the future development of intranasal vaccines.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1573037/fullinfectious diseasevaccinemucosal vaccinationintranasal immunizationdelivery system |
| spellingShingle | Zhihan Zhang Yumeng Yang Liwen Huang Lei Yuan Sijian Huang Zihang Zeng Yuan Cao Yuan Cao Xianghong Wei Xiaomei Wang Mingsong Shi Maohua Zhong Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases Frontiers in Immunology infectious disease vaccine mucosal vaccination intranasal immunization delivery system |
| title | Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases |
| title_full | Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases |
| title_fullStr | Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases |
| title_full_unstemmed | Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases |
| title_short | Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases |
| title_sort | nanotechnology driven advances in intranasal vaccine delivery systems against infectious diseases |
| topic | infectious disease vaccine mucosal vaccination intranasal immunization delivery system |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1573037/full |
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