Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the commun...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-07-01
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| Online Access: | https://doi.org/10.1177/25152564251330069 |
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| author | Michela Rossini Tânia Fernandes Irene D’Arsiè Riccardo Filadi |
| author_facet | Michela Rossini Tânia Fernandes Irene D’Arsiè Riccardo Filadi |
| author_sort | Michela Rossini |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks. |
| format | Article |
| id | doaj-art-a6eb0c90650f4143a6776bc851c2f313 |
| institution | DOAJ |
| issn | 2515-2564 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj-art-a6eb0c90650f4143a6776bc851c2f3132025-08-20T02:39:42ZengSAGE PublishingContact2515-25642025-07-01810.1177/25152564251330069Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s DiseaseMichela Rossini0Tânia Fernandes1Irene D’Arsiè2Riccardo Filadi3 Institute of Neuroscience, , Padua, Italy Department of Biomedical Sciences, , Padua, Italy Institute of Neuroscience, , Padua, Italy Institute of Neuroscience, , Padua, ItalyAlzheimer's disease (AD) is the most common neurodegenerative disorder of the elderly and no cure is currently available, as the mechanisms leading to neuronal damage and cognitive impairments remain elusive. In the last years, accumulating evidence highlighted early perturbations of the communication between mitochondria and endoplasmic reticulum (ER) in AD models. In this short review, we summarize recent findings linking alterations of ER-mitochondria coupling with typical AD hallmarks.https://doi.org/10.1177/25152564251330069 |
| spellingShingle | Michela Rossini Tânia Fernandes Irene D’Arsiè Riccardo Filadi Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease Contact |
| title | Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease |
| title_full | Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease |
| title_fullStr | Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease |
| title_full_unstemmed | Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease |
| title_short | Endoplasmic reticulum-Mitochondria Coupling in Alzheimer’s Disease |
| title_sort | endoplasmic reticulum mitochondria coupling in alzheimer s disease |
| url | https://doi.org/10.1177/25152564251330069 |
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