Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress
Purpose The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the assoc...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2025-06-01
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| Series: | International Neurourology Journal |
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| Online Access: | http://einj.org/upload/pdf/inj-2448460-230.pdf |
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| author | Zhao Luo Su Jin Kim Jiangnan Xu Chuan Lin Yu Seob Shin |
| author_facet | Zhao Luo Su Jin Kim Jiangnan Xu Chuan Lin Yu Seob Shin |
| author_sort | Zhao Luo |
| collection | DOAJ |
| description | Purpose The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the association between elevated LAP indices and SUI in women, specifically examining the mediating effects of oxidative stress and inflammatory factors. Methods Data from 4,292 participants across 6 consecutive cycles of the National Health and Nutrition Examination Survey were analyzed. Logistic regression and subgroup analyses, adjusted for various covariates, were performed to investigate the relationship between LAP and the prevalence of SUI in adult women. Additionally, mediation analysis was conducted to evaluate the contributions of oxidative stress and inflammatory factors to this association. Results The prevalence of SUI among women in the United States was 46.02%. After adjustment for confounding factors, the odds ratio for LAP and SUI was 1.003 (95% confidence interval, 1.001–1.004; P=0.002), indicating a positive association. Gamma-glutamyl transferase mediated this relationship, explaining 40.0% of the effect (P=0.036). Conclusions This study’s findings indicate a positive association between LAP and the prevalence of SUI in women, with oxidative stress potentially acting as a mediator in this relationship. |
| format | Article |
| id | doaj-art-a6dbc8a706a5468d8da8bb6d657ff506 |
| institution | Kabale University |
| issn | 2093-4777 2093-6931 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj-art-a6dbc8a706a5468d8da8bb6d657ff5062025-08-20T03:58:45ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312025-06-012929210210.5213/inj.2448460.2301159Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative StressZhao Luo0Su Jin Kim1Jiangnan Xu2Chuan Lin3Yu Seob Shin4 Department of Urology, Shenzhen Qianhai Taikang Hospital, Shenzhen, China Department of Urology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea Department of Urology, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, The First people’s Hospital of Yancheng, Jiangsu, China Department of Obstetrics and Gynecology, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Sichuan, China Department of Urology, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, KoreaPurpose The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the association between elevated LAP indices and SUI in women, specifically examining the mediating effects of oxidative stress and inflammatory factors. Methods Data from 4,292 participants across 6 consecutive cycles of the National Health and Nutrition Examination Survey were analyzed. Logistic regression and subgroup analyses, adjusted for various covariates, were performed to investigate the relationship between LAP and the prevalence of SUI in adult women. Additionally, mediation analysis was conducted to evaluate the contributions of oxidative stress and inflammatory factors to this association. Results The prevalence of SUI among women in the United States was 46.02%. After adjustment for confounding factors, the odds ratio for LAP and SUI was 1.003 (95% confidence interval, 1.001–1.004; P=0.002), indicating a positive association. Gamma-glutamyl transferase mediated this relationship, explaining 40.0% of the effect (P=0.036). Conclusions This study’s findings indicate a positive association between LAP and the prevalence of SUI in women, with oxidative stress potentially acting as a mediator in this relationship.http://einj.org/upload/pdf/inj-2448460-230.pdfnutrition surveyslipid accumulation productstress urinary incontinencemediation analysisoxidative stress |
| spellingShingle | Zhao Luo Su Jin Kim Jiangnan Xu Chuan Lin Yu Seob Shin Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress International Neurourology Journal nutrition surveys lipid accumulation product stress urinary incontinence mediation analysis oxidative stress |
| title | Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress |
| title_full | Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress |
| title_fullStr | Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress |
| title_full_unstemmed | Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress |
| title_short | Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress |
| title_sort | association between lipid accumulation product and stress urinary incontinence in women in the united states the mediating role of oxidative stress |
| topic | nutrition surveys lipid accumulation product stress urinary incontinence mediation analysis oxidative stress |
| url | http://einj.org/upload/pdf/inj-2448460-230.pdf |
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