Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review
Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological processes essential for overall health. REV-ERB, a ke...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516279/full |
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| author | Chunling Wang Jiashu Yang Jianfang Yuan Xuyong Wang Qianrong Li Chunzhen Ren Xiaodong Zhi Xiaodong Zhi Xinfang Lv Kai Liu Xinke Zhao Yingdong Li |
| author_facet | Chunling Wang Jiashu Yang Jianfang Yuan Xuyong Wang Qianrong Li Chunzhen Ren Xiaodong Zhi Xiaodong Zhi Xinfang Lv Kai Liu Xinke Zhao Yingdong Li |
| author_sort | Chunling Wang |
| collection | DOAJ |
| description | Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological processes essential for overall health. REV-ERB, a key circadian clock-regulating gene, plays a crucial role in maintaining the precision of these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health and well-being are increasingly challenged by disruptions to the biological clock, such as night shifts, late-night activities, and jet lag. These disruptions often lead to circadian rhythm disorders, which are now being increasingly linked to heart diseases. This review explored the potential role of REV-ERB in the cardiovascular system. Beyond its role in circadian rhythm regulation, REV-ERB could significantly influence physiological and pathological processes related to cardiovascular health, including atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure. Mechanistically, REV-ERB could regulate glucose and lipid metabolism, inflammation, autophagy, ferroptosis, and mitochondrial function. The review highlighted the protective roles and underlying mechanisms of REV-ERB in cardiovascular diseases, suggesting that multidisciplinary research may provide a basis for breakthroughs in REV-ERB-targeted therapies for cardiovascular disorders. |
| format | Article |
| id | doaj-art-a6d8429874b34b02bdadae7cf5ec940a |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-a6d8429874b34b02bdadae7cf5ec940a2025-08-20T03:07:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-04-011210.3389/fcvm.2025.15162791516279Role of circadian transcription factor REV-ERB in cardiovascular diseases: a reviewChunling Wang0Jiashu Yang1Jianfang Yuan2Xuyong Wang3Qianrong Li4Chunzhen Ren5Xiaodong Zhi6Xiaodong Zhi7Xinfang Lv8Kai Liu9Xinke Zhao10Yingdong Li11School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaDepartment of Geriatrics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaDepartment of Geriatrics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaGansu Medical College, Pingliang, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaCircadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological processes essential for overall health. REV-ERB, a key circadian clock-regulating gene, plays a crucial role in maintaining the precision of these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health and well-being are increasingly challenged by disruptions to the biological clock, such as night shifts, late-night activities, and jet lag. These disruptions often lead to circadian rhythm disorders, which are now being increasingly linked to heart diseases. This review explored the potential role of REV-ERB in the cardiovascular system. Beyond its role in circadian rhythm regulation, REV-ERB could significantly influence physiological and pathological processes related to cardiovascular health, including atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure. Mechanistically, REV-ERB could regulate glucose and lipid metabolism, inflammation, autophagy, ferroptosis, and mitochondrial function. The review highlighted the protective roles and underlying mechanisms of REV-ERB in cardiovascular diseases, suggesting that multidisciplinary research may provide a basis for breakthroughs in REV-ERB-targeted therapies for cardiovascular disorders.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516279/fullcircadian rhythmtranscription factorREV-ERBcardiovascular diseasesbiological clock regulation |
| spellingShingle | Chunling Wang Jiashu Yang Jianfang Yuan Xuyong Wang Qianrong Li Chunzhen Ren Xiaodong Zhi Xiaodong Zhi Xinfang Lv Kai Liu Xinke Zhao Yingdong Li Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review Frontiers in Cardiovascular Medicine circadian rhythm transcription factor REV-ERB cardiovascular diseases biological clock regulation |
| title | Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review |
| title_full | Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review |
| title_fullStr | Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review |
| title_full_unstemmed | Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review |
| title_short | Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review |
| title_sort | role of circadian transcription factor rev erb in cardiovascular diseases a review |
| topic | circadian rhythm transcription factor REV-ERB cardiovascular diseases biological clock regulation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1516279/full |
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