Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report
Reactivation of hepatitis B virus (HBV; RHBV) is a significant concern during immunosuppressive therapy, as it can lead to severe hepatitis and liver failure. The article reports a case of RHBV during treatment with guselkumab, an interleukin-23 inhibitor in a patient with inactive HBV infection and...
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| Format: | Article |
| Language: | English |
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Open Exploration
2023-12-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100831/100831.pdf |
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| author | Elena Franchi Arianna A. C. Costanzo Carmela Cursaro Amedeo Lonardo Claudia Lasagni Pietro Andreone |
| author_facet | Elena Franchi Arianna A. C. Costanzo Carmela Cursaro Amedeo Lonardo Claudia Lasagni Pietro Andreone |
| author_sort | Elena Franchi |
| collection | DOAJ |
| description | Reactivation of hepatitis B virus (HBV; RHBV) is a significant concern during immunosuppressive therapy, as it can lead to severe hepatitis and liver failure. The article reports a case of RHBV during treatment with guselkumab, an interleukin-23 inhibitor in a patient with inactive HBV infection and psoriasis. This report highlights the importance of screening for HBV prior to immunosuppressive therapy and initiating prophylactic therapy when necessary to prevent reactivation and its complications. |
| format | Article |
| id | doaj-art-a6d5de978c0540729b1f7f1da45e40b8 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-a6d5de978c0540729b1f7f1da45e40b82025-02-08T03:44:56ZengOpen ExplorationExploration of Drug Science2836-76772023-12-011646847410.37349/eds.2023.00031Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case reportElena Franchi0https://orcid.org/0000-0001-6217-2914Arianna A. C. Costanzo1Carmela Cursaro2https://orcid.org/0000-0002-5644-2508Amedeo Lonardo3https://orcid.org/0000-0001-9886-0698Claudia Lasagni4Pietro Andreone5https://orcid.org/0000-0002-4794-9809Postgraduate school of Internal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyPostgraduate school of Internal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyDepartment of Internal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyDepartment of Internal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyDepartment of Dermatology, Head and Neck Skin Cancer Service, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyDepartment of Internal Medicine and Chief of postgraduate school of Allergy and Clinical Immunology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, 41126 Modena, ItalyReactivation of hepatitis B virus (HBV; RHBV) is a significant concern during immunosuppressive therapy, as it can lead to severe hepatitis and liver failure. The article reports a case of RHBV during treatment with guselkumab, an interleukin-23 inhibitor in a patient with inactive HBV infection and psoriasis. This report highlights the importance of screening for HBV prior to immunosuppressive therapy and initiating prophylactic therapy when necessary to prevent reactivation and its complications.https://www.explorationpub.com/uploads/Article/A100831/100831.pdfhepatitis b infectionreactivationguselkumabpsoriasis |
| spellingShingle | Elena Franchi Arianna A. C. Costanzo Carmela Cursaro Amedeo Lonardo Claudia Lasagni Pietro Andreone Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report Exploration of Drug Science hepatitis b infection reactivation guselkumab psoriasis |
| title | Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report |
| title_full | Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report |
| title_fullStr | Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report |
| title_full_unstemmed | Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report |
| title_short | Reactivation of latent hepatitis B infection during immunosuppressive therapy with guselkumab for plaque psoriasis: a case report |
| title_sort | reactivation of latent hepatitis b infection during immunosuppressive therapy with guselkumab for plaque psoriasis a case report |
| topic | hepatitis b infection reactivation guselkumab psoriasis |
| url | https://www.explorationpub.com/uploads/Article/A100831/100831.pdf |
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