The molecular mechanisms by which the NLRP3 inflammasome regulates blood-brain barrier permeability following cryptococcal meningitis

The molecular mechanisms by which the NLRP3 inflammasome regulates blood-brain barrier permeability following cryptococcal meningitis

Objective: To investigate the mechanism underlying the regulation of blood-brain barrier permeability changes during cryptococcal meningitis by NLRP3 and Vimentin. Methods: Sprague-Dawley rats were treated with WT Cryptococcus neoformans (Cn) or CPS1−/− Cn. Neuronal apoptosis was assessed using TUNE...

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Bibliographic Details
Main Authors: Lingjuan Liu, Yufen Tang, Lu Zhang, Peng Huang, Xingfang Li, Yangyang Xiao, Dingan Mao, Liqun Liu, Jie Xiong
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Cryptococcal meningitis
NLRP3
Vimentin
Blood-brain barrier
Permeability
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024156848
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