Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine.

Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine.

Adhesion of E. coli to the urinary tract epithelium is a critical step in establishing urinary tract infections. FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (FimHLD). FimH is of interest as a target of v...

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Main Authors: Natalie C Silmon de Monerri, Ye Che, Joshua A Lees, Jayasankar Jasti, Huixian Wu, Matthew C Griffor, Srinivas Kodali, Julio Cesar Hawkins, Jacqueline Lypowy, Christopher Ponce, Kieran Curley, Alexandre Esadze, Juan Carcamo, Thomas McLellan, David Keeney, Arthur Illenberger, Yury V Matsuka, Suman Shanker, Laurent Chorro, Alexey V Gribenko, Seungil Han, Annaliesa S Anderson, Robert G K Donald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012325
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