Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges

Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges

Acute kidney injury (AKI) is a clinical syndrome associated with considerable morbidity and mortality. Despite therapeutic advancements, renal recovery and long-term outcomes remain suboptimal. Understanding the pathogenesis of AKI and identifying strategies to prevent its progression have become cr...

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Bibliographic Details
Main Authors: Meiling Cao, Xueqi Zhao, Fang Xia, Mingyue Shi, Danyang Zhao, Lei Li, Hongkun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Physiology
Subjects:
acute kidney injury (AKI)
energy metabolic reprogramming
mitochondrial dysfunction
proximal tubular cells (PTC)
therapeutic implications
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1623500/full
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