The effects of treadmill exercise and diet control on cognitive function in HFD-induced ApoE-/- mice based on the SIRT1-NF-κB/PGC-1α-BDNF signaling pathways

The effects of treadmill exercise and diet control on cognitive function in HFD-induced ApoE-/- mice based on the SIRT1-NF-κB/PGC-1α-BDNF signaling pathways

[Objective] To investigate the effect and mechanism of treadmill exercise and diet control on cognitive dysfunction in apolipoprotein E knockout(ApoE-/-)mice model. [Methods] Forty ApoE -/- male mice fed a high-fat diet for 8 weeks were randomly and equally divided into a high-fat diet exercise (HFD...

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Bibliographic Details
Main Authors: Xu Ting, Deng Wenjuan, Li Shufeng, Liu Yi, Shi Zhitong, Zhang Xiaoyue, Wang Ningping
Format: Article
Language:zho
Published: Editorial Office of International Journal of Geriatrics 2025-05-01
Series:Guoji laonian yixue zazhi
Subjects:
exercise
diet control
high-fat diet
sirt1-nf-κb
pgc-1α-bdnf
cognitive function
Online Access:http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.03.007&lang=en
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