Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems
Psoriasis, chronic eczema and atopic dermatitis are the most common diseases among patients of dermatovenereological profile. The study of the etiology and pathogenesis of chronic dermatoses, and the grounded choice of their treatment are extremely important problems of modern medicine. The objec...
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| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2016-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/82602/78778 |
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| author | N. Yu. Reznichenko |
| author_facet | N. Yu. Reznichenko |
| author_sort | N. Yu. Reznichenko |
| collection | DOAJ |
| description | Psoriasis, chronic eczema and atopic dermatitis are the most common diseases among patients of dermatovenereological profile. The study of the etiology and pathogenesis of chronic dermatoses, and the grounded choice of their treatment are extremely important problems of modern medicine.
The objective of this work was to study the peculiarities of functioning of sympathoadrenal and vagal-insular systems in male patients with psoriasis, chronic eczema and atopic dermatitis.
Materials and methods. 115 healthy males and males who suffered from psoriasis, chronic eczema and atopic dermatitis were examined. The men were distributed in the study groups depending on their age and the presence of chronic dermatoses. We investigated levels of adrenaline, norepinephrine, dioxyphenylalanine, dopamine in urine, as well as the levels of insulin and cortisol in blood. The calculation of hormones and mediators ratios of the sympathoadrenal and autonomic systems was performed.
Results. Sympathoadrenal system was less active and its reserve capacity was lower in males with psoriasis, chronic eczema and atopic dermatitis. We also fixed the acceleration of biosynthesis of catecholamines. The speed of transformation of dioxyphenilalanine and dopamine to their metabolites was higher in patients with psoriasis, chronic eczema and atopic dermatitis. The high tension of glucocorticoid function of adrenal glands and increased activity of autonomic system; the intensive violations of autonomic homeostasis; the reduction of activity of compensatory organism reactions were found in male patients with chronic dermatoses. The discoordinated relationships in neurogenic link of adaptation in patients with chronic dermatoses were fixed. An antagonistic relationship was also revealed between different branches of nervous system in patients with psoriasis, chronic eczema and atopic dermatitis. These data reflected the violations of adaptation in patients with chronic dermatoses.
Conclusions. The obtained results indicate the existence of irregularities in the functioning of the sympathoadrenal and autonomic systems. The results of investigation substantiate the feasibility of corrective measures in male patients with chronic dermatoses (such as psoriasis, chronic eczema, atopic dermatitis), by the using of drugs that improve metabolism in the brain. |
| format | Article |
| id | doaj-art-a6cb76ed66ce48c6a9079032ea1bf103 |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-a6cb76ed66ce48c6a9079032ea1bf1032025-08-20T03:19:02ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102016-10-0153942http://dx.doi.org/10.14739/2310-1210.2016.5.82602Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systemsN. Yu. ReznichenkoPsoriasis, chronic eczema and atopic dermatitis are the most common diseases among patients of dermatovenereological profile. The study of the etiology and pathogenesis of chronic dermatoses, and the grounded choice of their treatment are extremely important problems of modern medicine. The objective of this work was to study the peculiarities of functioning of sympathoadrenal and vagal-insular systems in male patients with psoriasis, chronic eczema and atopic dermatitis. Materials and methods. 115 healthy males and males who suffered from psoriasis, chronic eczema and atopic dermatitis were examined. The men were distributed in the study groups depending on their age and the presence of chronic dermatoses. We investigated levels of adrenaline, norepinephrine, dioxyphenylalanine, dopamine in urine, as well as the levels of insulin and cortisol in blood. The calculation of hormones and mediators ratios of the sympathoadrenal and autonomic systems was performed. Results. Sympathoadrenal system was less active and its reserve capacity was lower in males with psoriasis, chronic eczema and atopic dermatitis. We also fixed the acceleration of biosynthesis of catecholamines. The speed of transformation of dioxyphenilalanine and dopamine to their metabolites was higher in patients with psoriasis, chronic eczema and atopic dermatitis. The high tension of glucocorticoid function of adrenal glands and increased activity of autonomic system; the intensive violations of autonomic homeostasis; the reduction of activity of compensatory organism reactions were found in male patients with chronic dermatoses. The discoordinated relationships in neurogenic link of adaptation in patients with chronic dermatoses were fixed. An antagonistic relationship was also revealed between different branches of nervous system in patients with psoriasis, chronic eczema and atopic dermatitis. These data reflected the violations of adaptation in patients with chronic dermatoses. Conclusions. The obtained results indicate the existence of irregularities in the functioning of the sympathoadrenal and autonomic systems. The results of investigation substantiate the feasibility of corrective measures in male patients with chronic dermatoses (such as psoriasis, chronic eczema, atopic dermatitis), by the using of drugs that improve metabolism in the brain.http://zmj.zsmu.edu.ua/article/view/82602/78778PsoriasisEczemaAtopic DermatitisMales |
| spellingShingle | N. Yu. Reznichenko Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems Zaporožskij Medicinskij Žurnal Psoriasis Eczema Atopic Dermatitis Males |
| title | Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems |
| title_full | Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems |
| title_fullStr | Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems |
| title_full_unstemmed | Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems |
| title_short | Psoriasis, chronic eczema and atopic dermatitis in males: functioning of sympathoadrenal and vagoinsular systems |
| title_sort | psoriasis chronic eczema and atopic dermatitis in males functioning of sympathoadrenal and vagoinsular systems |
| topic | Psoriasis Eczema Atopic Dermatitis Males |
| url | http://zmj.zsmu.edu.ua/article/view/82602/78778 |
| work_keys_str_mv | AT nyureznichenko psoriasischroniceczemaandatopicdermatitisinmalesfunctioningofsympathoadrenalandvagoinsularsystems |