4-(1<i>H</i>-Tetrazol-5-yl)-2-(<i>p</i>-tolyl)quinoline

4-(1<i>H</i>-Tetrazol-5-yl)-2-(<i>p</i>-tolyl)quinoline

The synthesis of 4-(1<i>H</i>-tetrazol-5-yl)-2-(<i>p</i>-tolyl)quinoline <b>4</b> as a possible modification of the biphenyltetrazole substructure of losartan <b>1</b> is described. The transformation of 2-(<i>p</i>-tolyl)quinoline-4-carbon...

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Bibliographic Details
Main Authors:	Angelika Lásiková, Daniel Végh
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Series:	Molbank
Subjects:	angiotensin II receptor antagonists analog of losartan 2,4-disubstituted quinoline synthesis of tetrazolylquinoline
Online Access:	https://www.mdpi.com/1422-8599/2024/4/M1897
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Summary:	The synthesis of 4-(1<i>H</i>-tetrazol-5-yl)-2-(<i>p</i>-tolyl)quinoline <b>4</b> as a possible modification of the biphenyltetrazole substructure of losartan <b>1</b> is described. The transformation of 2-(<i>p</i>-tolyl)quinoline-4-carbonitrile <b>3</b> to the corresponding tetrazole <b>4</b> was carried out by the reaction of trimethysilyl azide and dibutyltin oxide as a catalyst in refluxing toluene. The title compound (<b>4</b>) was characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS.
ISSN:	1422-8599