High heritability is compatible with the broad distribution of set point viral load in HIV carriers.
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors contribute substantially to the overall variatio...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-02-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004634&type=printable |
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| _version_ | 1849726848948240384 |
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| author | Sebastian Bonhoeffer Christophe Fraser Gabriel E Leventhal |
| author_facet | Sebastian Bonhoeffer Christophe Fraser Gabriel E Leventhal |
| author_sort | Sebastian Bonhoeffer |
| collection | DOAJ |
| description | Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors contribute substantially to the overall variation in viral load. The high heritability is surprising given the diversity of host factors associated with controlling viral infection. Here we develop an analytical model that describes the temporal changes of the distribution of set point viral load as a function of heritability. This model shows that high heritability is the most parsimonious explanation for the observed variance of set point viral load. Our results thus not only reinforce the credibility of previous estimates of heritability but also shed new light onto mechanisms of viral pathogenesis. |
| format | Article |
| id | doaj-art-a6c325aa6d47445fb60f196fae3a0ab4 |
| institution | DOAJ |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-a6c325aa6d47445fb60f196fae3a0ab42025-08-20T03:10:04ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742015-02-01112e100463410.1371/journal.ppat.1004634High heritability is compatible with the broad distribution of set point viral load in HIV carriers.Sebastian BonhoefferChristophe FraserGabriel E LeventhalSet point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors contribute substantially to the overall variation in viral load. The high heritability is surprising given the diversity of host factors associated with controlling viral infection. Here we develop an analytical model that describes the temporal changes of the distribution of set point viral load as a function of heritability. This model shows that high heritability is the most parsimonious explanation for the observed variance of set point viral load. Our results thus not only reinforce the credibility of previous estimates of heritability but also shed new light onto mechanisms of viral pathogenesis.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004634&type=printable |
| spellingShingle | Sebastian Bonhoeffer Christophe Fraser Gabriel E Leventhal High heritability is compatible with the broad distribution of set point viral load in HIV carriers. PLoS Pathogens |
| title | High heritability is compatible with the broad distribution of set point viral load in HIV carriers. |
| title_full | High heritability is compatible with the broad distribution of set point viral load in HIV carriers. |
| title_fullStr | High heritability is compatible with the broad distribution of set point viral load in HIV carriers. |
| title_full_unstemmed | High heritability is compatible with the broad distribution of set point viral load in HIV carriers. |
| title_short | High heritability is compatible with the broad distribution of set point viral load in HIV carriers. |
| title_sort | high heritability is compatible with the broad distribution of set point viral load in hiv carriers |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004634&type=printable |
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