Infective endocarditis in a developing country: evaluation of 230 cases
AIM: In this study it was aimed to analyse the clinical characteristics and outcomes of IE cases in our hospital. BACKGROUND: Despite developments in antibiotics and medicine, infective endocarditis (IE) is associated with significant morbidity and mortality. METHODS: Patients that were followed up...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003199 |
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| author | Oğuzhan Acet Deniz Akyol Seyhan Selin Bardak Özcem Gunel Guliyeva Meral Kayıkçıoğlu Tansu Yamazhan Hüsnü Pullukçu Bilgin Arda Sercan Ulusoy Hilal Sipahi Meltem Taşbakan Oğuz Reşat Sipahi |
| author_facet | Oğuzhan Acet Deniz Akyol Seyhan Selin Bardak Özcem Gunel Guliyeva Meral Kayıkçıoğlu Tansu Yamazhan Hüsnü Pullukçu Bilgin Arda Sercan Ulusoy Hilal Sipahi Meltem Taşbakan Oğuz Reşat Sipahi |
| author_sort | Oğuzhan Acet |
| collection | DOAJ |
| description | AIM: In this study it was aimed to analyse the clinical characteristics and outcomes of IE cases in our hospital. BACKGROUND: Despite developments in antibiotics and medicine, infective endocarditis (IE) is associated with significant morbidity and mortality. METHODS: Patients that were followed up for definite IE (diagnosed according to modified Duke criteria) in ourhospital between March 2007 and September 2023 were analyzed retrospectively. Patients were evaluated in terms of demographic features,underlying diseases, risk factors, clinical and laboratory findings, therapy responses, complications, and mortality. RESULTS: There were 230 patients diagnosed with IE [79-52.6% femaie, aged 53.3±16.9 years, ranging 18-92 years] fulfilling the study inclusion criteria. Risk factors, complaints, laboratory findings and complications of patients was shown in Table 1. Blood culture was positive in 175 patients (75,5%). The most common etiologic agents were; S. viridans (26.08%), S. aureus (18.6%) and E. feacalis (10.8%). The antibiotherapy of 40 patients with native valve endocarditis comprised ampicillin/sulbactam and gentamicin (other therapy combinations were vancomycin and gentamicin [n=11], penicillin and gentamicin[n=38]). Nine of 49 patients with prosthetic valve endocarditis were treated with vancomycin, rifampicin and gentamicin while other nine were treated with daptomycin including therapy. In hospital mortality was (20%-46/230). Mortality rates between blood culture positive and negative cases were similar (Chi-square test p=1) while mortality in S. viridans was less than S. aureus or enterococci (Chi-square test p=0.0085, Table 2). CONCLUSIONS: IE is still associated with significant mortality. More interventions are needed to further decrease the complication and mortality rates. |
| format | Article |
| id | doaj-art-a6bc280f454840bc8779f0e9f49d85a0 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-a6bc280f454840bc8779f0e9f49d85a02024-12-27T04:08:35ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-013944Infective endocarditis in a developing country: evaluation of 230 casesOğuzhan Acet0Deniz Akyol Seyhan1Selin Bardak Özcem2Gunel Guliyeva3Meral Kayıkçıoğlu4Tansu Yamazhan5Hüsnü Pullukçu6Bilgin Arda7Sercan Ulusoy8Hilal Sipahi9Meltem Taşbakan10Oğuz Reşat Sipahi11Department of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Kanuni Sultan Süleyman Research and Teaching Hospital, İstanbul, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Near East University, Nicosia, CyprusDepartment of Infectious Diseases and Clinical Microbiology, Liv Bona Dea Hospital, Baku, AzerbaijanDepartment of Cardiology, Ege University, İzmir, TurkiyeDepartment of Cardiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeBornova Directorate of Health, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeAIM: In this study it was aimed to analyse the clinical characteristics and outcomes of IE cases in our hospital. BACKGROUND: Despite developments in antibiotics and medicine, infective endocarditis (IE) is associated with significant morbidity and mortality. METHODS: Patients that were followed up for definite IE (diagnosed according to modified Duke criteria) in ourhospital between March 2007 and September 2023 were analyzed retrospectively. Patients were evaluated in terms of demographic features,underlying diseases, risk factors, clinical and laboratory findings, therapy responses, complications, and mortality. RESULTS: There were 230 patients diagnosed with IE [79-52.6% femaie, aged 53.3±16.9 years, ranging 18-92 years] fulfilling the study inclusion criteria. Risk factors, complaints, laboratory findings and complications of patients was shown in Table 1. Blood culture was positive in 175 patients (75,5%). The most common etiologic agents were; S. viridans (26.08%), S. aureus (18.6%) and E. feacalis (10.8%). The antibiotherapy of 40 patients with native valve endocarditis comprised ampicillin/sulbactam and gentamicin (other therapy combinations were vancomycin and gentamicin [n=11], penicillin and gentamicin[n=38]). Nine of 49 patients with prosthetic valve endocarditis were treated with vancomycin, rifampicin and gentamicin while other nine were treated with daptomycin including therapy. In hospital mortality was (20%-46/230). Mortality rates between blood culture positive and negative cases were similar (Chi-square test p=1) while mortality in S. viridans was less than S. aureus or enterococci (Chi-square test p=0.0085, Table 2). CONCLUSIONS: IE is still associated with significant mortality. More interventions are needed to further decrease the complication and mortality rates.http://www.sciencedirect.com/science/article/pii/S2213716524003199Infective endocarditisProsthetic valve endocarditisNative valve endocarditis |
| spellingShingle | Oğuzhan Acet Deniz Akyol Seyhan Selin Bardak Özcem Gunel Guliyeva Meral Kayıkçıoğlu Tansu Yamazhan Hüsnü Pullukçu Bilgin Arda Sercan Ulusoy Hilal Sipahi Meltem Taşbakan Oğuz Reşat Sipahi Infective endocarditis in a developing country: evaluation of 230 cases Journal of Global Antimicrobial Resistance Infective endocarditis Prosthetic valve endocarditis Native valve endocarditis |
| title | Infective endocarditis in a developing country: evaluation of 230 cases |
| title_full | Infective endocarditis in a developing country: evaluation of 230 cases |
| title_fullStr | Infective endocarditis in a developing country: evaluation of 230 cases |
| title_full_unstemmed | Infective endocarditis in a developing country: evaluation of 230 cases |
| title_short | Infective endocarditis in a developing country: evaluation of 230 cases |
| title_sort | infective endocarditis in a developing country evaluation of 230 cases |
| topic | Infective endocarditis Prosthetic valve endocarditis Native valve endocarditis |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524003199 |
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