Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature
Juvenile dermatomyositis (JDM) is the most common type of inflammatory myositis in childhood, characterized by proximal muscle weakness and rash. The standard treatment of JDM involves steroids and methotrexate (MTX). A small proportion of patients do not respond to steroids and MTX. We present a co...
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=205;epage=208;aulast=Rao |
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| author | Anand Prahalad Rao Vinyasa Kolli Indhuja Rajarathinam Jyothi Raghuram |
| author_facet | Anand Prahalad Rao Vinyasa Kolli Indhuja Rajarathinam Jyothi Raghuram |
| author_sort | Anand Prahalad Rao |
| collection | DOAJ |
| description | Juvenile dermatomyositis (JDM) is the most common type of inflammatory myositis in childhood, characterized by proximal muscle weakness and rash. The standard treatment of JDM involves steroids and methotrexate (MTX). A small proportion of patients do not respond to steroids and MTX. We present a couple of patients with refractory JDM who had failed to respond to steroids and MTX. Introduction of tacrolimus led to complete remission of the disease in a patient and partial control in the other. Literature review was done which revealed ten patients with JDM who were treated with tacrolimus with encouraging results in the form of significant reduction in the cutaneous and muscle disease activity. Tacrolimus is an useful drug in the management of refractory JDM. |
| format | Article |
| id | doaj-art-a6b7e47a08ee402292b931f63ec55dae |
| institution | OA Journals |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-a6b7e47a08ee402292b931f63ec55dae2025-08-20T01:47:45ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115620520810.4103/injr.injr_128_20Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literatureAnand Prahalad RaoVinyasa KolliIndhuja RajarathinamJyothi RaghuramJuvenile dermatomyositis (JDM) is the most common type of inflammatory myositis in childhood, characterized by proximal muscle weakness and rash. The standard treatment of JDM involves steroids and methotrexate (MTX). A small proportion of patients do not respond to steroids and MTX. We present a couple of patients with refractory JDM who had failed to respond to steroids and MTX. Introduction of tacrolimus led to complete remission of the disease in a patient and partial control in the other. Literature review was done which revealed ten patients with JDM who were treated with tacrolimus with encouraging results in the form of significant reduction in the cutaneous and muscle disease activity. Tacrolimus is an useful drug in the management of refractory JDM.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=205;epage=208;aulast=Raojuvenile dermatomyositismethotrexate tacrolimusrefractory |
| spellingShingle | Anand Prahalad Rao Vinyasa Kolli Indhuja Rajarathinam Jyothi Raghuram Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature Indian Journal of Rheumatology juvenile dermatomyositis methotrexate tacrolimus refractory |
| title | Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature |
| title_full | Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature |
| title_fullStr | Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature |
| title_full_unstemmed | Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature |
| title_short | Tacrolimus in refractory juvenile dermatomyositis: Case report and review of literature |
| title_sort | tacrolimus in refractory juvenile dermatomyositis case report and review of literature |
| topic | juvenile dermatomyositis methotrexate tacrolimus refractory |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=205;epage=208;aulast=Rao |
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